The development of automated servers to predict the three-dimensional structure of proteins has seen much progress over the years. These servers make calculations simpler, but largely exclude users from the process. In this study, we present the PRotein Interactive MOdeling (PRIMO) pipeline for homology modeling of protein monomers. The pipeline eases the multi-step modeling process, and reduce...

The University of Kansas (KU) Libraries first made their discovery tool, Primo (Ex Libris), available to their users in the fall of 2013. Since that time, in spite of many upgrades and improvements, most librarians and library staff are still not using the tool for their own research. Last year, librarians from KU presented their findings at the Charleston Conference using a survey given to KU ...

The primo vascular system (PVS) is being established as a circulatory system that corresponds to acupuncture meridians. There have been two critical questions in making the PVS accepted as a novel liquid flowing system. The first one was directly to show the flow of liquid in PVS and the second one was to explain why it was not observed in the conventional histological study of animal tissues. ...

Introduction: Nowadays Intensity Modulated Radiotherapy (IMRT) is a common method for treating prostate cancers. Must of the Monte Carlo software cannot simulate the IMRT procedures due to inability of these soft wares to simulate the multi leaf collimator (MLC) positions or movements. A new user-friendly software based on the PENELOPE Monte Carlo code named PRIMO was published...

Introduction: In radiation therapy, in order to double-check the dosimetric results of the main treatment planning system (TPS), a distinct TPS, with few capacitances in terms of contouring and a variety of dose calculation algorithms is used. This system has the capability to double check the planification and the accurate prediction of dose distribution in order to be ensured...

We studied the action potential of Primo-vessels in rats to determine the electrophysiological characteristics of these structures. We introduced a mathematical analysis method, a normalized Fourier transform that displays the sine and cosine components separately, to compare the action potentials of Primo-vessels with those for the smooth muscle. We found that Primo-vessels generated two types...

An extension of the recently developed PRIMO coarse-grained force field to membrane environments, PRIMO-M, is described. The membrane environment is modeled with the heterogeneous dielectric generalized Born (HDGB) methodology that simply replaces the standard generalized Born model in PRIMO without further parametrization. The resulting model was validated by comparing amino acid insertion fre...

Corresponding author: Nicola Lucio Liberato MD Internal Medicine Ospedale C. Mira Piazzale Volontari del Sangue 27022 Casorate Primo (PV), Italy Phone: +390290040224 Fax: +390290040304 E-mail: lucio_liberato@ ospedali.pavia.it 1 Internal Medicine, Azienda Ospedaliera della Provincia di Pavia, Ospedale Civile “Asilo Vittoria”, Mortara (PV), Italy 2 Internal Medicine, Azienda Ospedaliera della Pr...

BACKGROUND Helicobacter pylori infection is one of the most common chronic infections in the world, and is acquired mainly during childhood. It is not clear to which extent a primary infection protects the child from reinfection. Our aim was to determine the possible protection conferred by a primary infection against H. pylori reinfection in children. METHODS A follow-up study with 120 child...

The University of Kansas (KU) Libraries first made the discovery tool, Primo (Ex Libris), available to their users in the fall of 2013. Since that time, in spite of many improvements and updates, librarians still prefer to use other resources. In an effort to facilitate open and honest discussion about the Primo discovery tool and to make recommendations to improve the functionality of the inst...