A cDNA library was prepared from peripheral blood lymphocytes of an autoimmune patient with primary Sjögrens' syndrome. The cDNA library was screened with the patients own autoimmune serum being monospecific for the nuclear autoantigen La/SS-B. Thereby an alternative type of La mRNA was identified that differed from the known La mRNA due to an exchange of the exon 1. Sequencing of the genomic r...

primary sjögren's syndrome (pss) is a common autoimmune disease involving abnormal th17 activation. the aim of the current study was to investigate the immunosuppression effect of cyclosporine a (cys a), a potent immunosuppressor on the proliferation and activation of t cells, on the activation of th17 cells. blood samples from both inactive and active pss patients as well as healthy controls w...

introduction camurati-engelmann disease (ced) is a rare autosomal dominant disease with various phenotypic expressions. the symptoms usually develop during childhood. the hallmark of the disease is bilateral symmetric diaphyseal hyperostosis of the long bones with progressive involvement of the metaphysis. the epiphysis is strictly spared. the common clinical symptoms are pain of the extremitie...

two-hundred and seventeen subjects underwent transvaginal ultrasound -17 (8%) had unilateral polycystic ovary (pco). twelve percent of subjects with unilateral scan-pea had oligomenorrhea, 24% were amenorrheic, 23% were hirsute and 29% had acne. biochemical parameters were compared between subjects with unilateral scan- pco and those with bilateral scan- pco (n=200) as well as a group of scan-n...

Background: Sj?gren’s syndrome is an autoimmune syndrome involving the exocrine glands specially the salivary and lacrimal glands leading to xerostomia and xerophtalmia. This paper presents a case with primary Sj?gren’s syndrome that severe dental caries were the first clinical manifestation. Case Presentation: A 42-year-old man was referred to the School of Dentistry, Tehran University of Medi...

background: sj?gren’s syndrome is an autoimmune syndrome involving the exocrine glands specially the salivary and lacrimal glands leading to xerostomia and xerophtalmia. this paper presents a case with primary sj?gren’s syndrome that severe dental caries were the first clinical manifestation. case presentation: a 42-year-old man was referred to the school of dentistry, tehran university of medi...

irritable bowel syndrome (ibs) is one of the most common gastrointestinal disorders particularly affecting the quality of life (qol). evaluating qol in ibs patients is a valuable method of defining a psychobiological pattern of disease. various disease specific and general instruments are now available to measure health-related qol (hrqol) in ibs patients. though, no comparison has been made be...

OBJECTIVE The association between Sjögren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections. MATERIALS AND METHODS We identified 9,629 SS patients without other concomitant...