introduction: there is evidence that diabetes affects seizure susceptibility. ginger (zingiber officinale roscoe) which is used in traditional medicine has antioxidant activity and neuroprotective effects. the aim of this study was to evaluate the seizure threshold induced by pentylenetetrazole (ptz) in diabetic mice after induction of diabetes with streptozocin and to examine the possible role...

PURPOSE Evaluate the efficacy of carbamazepine in the treatment of idiopathic generalized epilepsy (IGE). METHOD The response of five patients with IGE, who experienced primarily generalized tonic-clonic seizures which were refractory to multiple antiepileptic drugs, is reported. RESULTS Carbamazepine controlled multiple seizure types and did not induce or increase the frequency of myocloni...

Seizures remain uncontrolled in 30% of patients with epilepsy, even with concurrent use of multiple drugs, and uncontrolled seizures result in increased morbidity and mortality. An extreme example is Dravet syndrome (DS), an infantile-onset severe epilepsy caused by heterozygous loss of function mutations in SCN1A, the gene encoding the brain type-I voltage-gated sodium channel NaV1.1. Studies ...

We describe a case of a 50-year-old Hispanic man diagnosed with HIV/AIDS who presented with a generalized tonic clonic seizure and ring enhancing cerebral lesions on imaging. He was initially treated for CNS toxoplasmosis but presented to the hospital with another tonic clonic seizure despite prescribed therapy. Brain biopsy was performed which revealed Nocardia beijingensis. He was treated wit...

In this report a 20-year-old male patient who had suffered tonic-clonic seizure after a single induction dose of etomidate until a bispectral index value of 60 is presented. Our best knowledge, this case is the first report of pure etomidate (with induction dose) induced generalized tonic clonic seizure proven with EEG. Anaesthesiologists should be careful against such a complication even in th...

We reported the case of a young woman who received an antiepileptic drug after a first possible generalized tonic-clonic seizure with no clear inter-ictal epileptic paroxysms in the routine electroencephalogram. Her stereotypical movements decreased but did not disappear with treatment. Then a diagnosis of PNES was considered by neurologist after witnessing a stereotypical motor episode. While ...