نتایج جستجو برای: primary c3 deficiency
تعداد نتایج: 784306 فیلتر نتایج به سال:
Apoptotic cells are a source of autoantigens and impairment of their removal contributes to the development of autoimmunity in C1q deficiency. However, the lack of complement component 3 (C3), the predominant complement opsonin, does not predispose to autoimmunity, suggesting a modifying role of C3 in disease pathogenesis. To explore this hypothesis, here we investigated the role of C3 in the T...
Background and Objectives: Complement proteins are some of the most important plasma proteins of the innate immune system. Impaired immune function is reported in subjects who are iron deficient, and there are documents that these patients are prone to infection. This study was conducted to show whether serum C3 and C4 complement change in adult nonpregnant female with iron deficient anemia or ...
Primary immunodeficiencies are inherited disorders of the immune system, with an estimated prevalence of 1:500 in the USA. Yet, a majority of the patients are still undiagnosed. Most patients with a diagnosis come in contact with the healthcare due to complications caused by the immunological defects. In many cases, it is crucial that the patients receive treatment before their health is seriou...
Dense deposit disease (DDD) is a severe renal disease characterized by accumulation of electron-dense material in the mesangium and glomerular basement membrane. Previously, DDD has been associated with deficiency of factor H (fH), a plasma regulator of the alternative pathway (AP) of complement activation, and studies in animal models have linked pathogenesis to the massive complement factor 3...
Abstract Background: Iron deficiency is the most common nutritional deficiencies in the world. So that 15% of the total world population is involved. The present study examined the association between iron deficiency anemia and primary hypothyroidism and the prevalence of iron deficiency anemia and primary hypothyroidism, respectively, in patients with iron deficiency anemia and primar...
Recent reports suggest that complement system contributes to allograft rejection. However, its underlying mechanism is poorly understood. Herein, we investigate the role of complement component 3 (C3) in a single MHC-II molecule mismatched murine model of allograft rejection using C3 deficient mice (C3(-/-)) as skin graft donors or recipients. Compared with C3(+/+) B6 allografts, C3(-/-) B6 gra...
patients with primary antibody deficiencies (pad) are susceptible to recurrent and chronic infections and a variety of complications. this study was performed to assess quality of life (qol) of pad patients who were under long term treatment and regular follow-up.thirty six adults with proved diagnosis of pad, who had received regular intravenous immunoglobulin replacement therapy, we...
the main clinical presentation of patients with primary antibody deficiency (pad) incorporates upper respiratory tract infections comprising otitis media, sinusitis and pneumonia. this study was designed to investigate clinical and paraclinical otological complications in major types of pad. a cross sectional study was conducted on 55 pad patients with diagnosis of selective iga ...
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