نتایج جستجو برای: primary and metastatic melanoma

تعداد نتایج: 16947239  

Journal: :medical journal of islamic republic of iran 0
s shamsadini from the departments of dermatology and * pathology, kerman university of medical sciences, kerman, i.r. iran. s dabiri

zosteriform metastasis is a rare clinical distribution from spreading neoplasms of every organ to the skin. tumors most often arise from a n internal o r hematologic malignancy. w e report a 69-year-old man, a known case of malignant melanoma of the left heel. in this case, multiple red-brown metastatic nodules appeared four months after diagnosis. distribution of metastatic lesions resembled a...

S DABIRI, S SHAMSADINI,

Zosteriform metastasis is a rare clinical distribution from spreading neoplasms of every organ to the skin. Tumors most often arise from a n internal o r hematologic malignancy. W e report a 69-year-old man, a known case of malignant melanoma of the left heel. In this case, multiple red-brown metastatic nodules appeared four months after diagnosis. Distribution of metastatic lesions resemb...

D Taheri G Faghihi N Ghanei P Rajabi

Background: P53 tumor suppressor gene mutation is one of the most common genetic alterations in human malignancies. The mutated from of the gene is stable and can be detected with immunohistochemistry methods. There is much controversy about the expression rate of this gene in malignant melanoma. Objective: To determine the frequency of the P53 antigen expression by sex, age, type and thickness...

Journal: :acta medica iranica 0
f. asadi amoli m. taher-rajabi m. r. esfahani a. sadeghi

non-hodgkin lymphoma (nhl) is one of the masquerade syndromes of malignant melanoma that can occur with two main patterns of presentations in the eye: metastatic involvement of uveal tract, and primary involvement of retina. we report ophthalmic, imaging and histopathological findings in the first case diagnosed as primary choroidal nhl without central nervous system or systemic involvement. a ...

Journal: :The professional medical journal 2023

Small bowel tumors are very rare. Melanoma in small intestine can be primary or metastatic. Metastatic malignant melanoma arise from skin, eyes, oropharynx, esophagus ano rectal mucosa. Primary melanomas of In this case report, we going to present intestine, which has already metastasized by the time presentation. A 60 year old male, presented us with abdominal pain, vomiting and absolute const...

2013
Weimin Liu Yuchun Luo Jeffrey H. Dunn David A. Norris Charles A. Dinarello Mayumi Fujita

Apoptosis-associated Speck-like protein containing a CARD (caspase recruitment domain) (ASC) was originally named because it triggered apoptosis in certain tumors. More recently, however, ASC was found to be a central adaptor protein of inflammasome, which mediates the secretion of protumorigenic inflammation. Here we examined the role of ASC in tumorigenesis of human melanoma. Compared with pr...

2015
Guohong Zhang Yabin Cheng Guangdi Chen Yun Tang Gholamreza Ardekani Anand Rotte Magdalena Martinka Kevin McElwee Xuezhu Xu Qi Wang Youwen Zhou

Primary melanoma, a highly aggressive malignancy, exhibits heterogeneity in biologic behaviors, clinical characteristics, metastasis potential and mortality. The present study sought to identify the molecular signatures that define a subgroup of primary melanomas with high risks of metastasis and mortality. First, we identified the markers that best differentiated metastatic melanomas from prim...

Journal: :Clinical journal of oncology nursing 2009
Kristin Simar

Although rare, uveal melanoma is the most common primary intraocular malignant tumor in adults. Over the past 50 years, the incidence in North America has been stable, with 4.3 per million (or about 1,500 cases per year) being newly diagnosed (Sato, Han, & Yamamoto, 2008). Uveal melanoma differs from cutaneous melanoma in a variety of ways, such as primary treatment, metastatic pattern, and ove...

Journal: :Acta cirurgica brasileira 2005
Andrea Fernandes de Oliveira Alfredo Gragnani Renato Santos Oliveira Filho Ivan Dunshee de Abranches Oliveira Santos Silvana Gaiba de França Mílvia Maria Simões e Silva Enokihara Lydia Masako Ferreira

PURPOSE Establish an experimental model of metastatic melanoma primary culture cells from fine-needle aspiration biopsies (FNAB). METHODS Two metastatic melanoma primary culture cells from (FNAB) have been developed from patients who had been submitted to excision of metastatic lesions and they were identified by immunohistochemical analyses using S-100 and MB-45 melanoma markers. RESULTS T...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011
Guangdi Chen Yabin Cheng Zhizhong Zhang Magdalena Martinka Gang Li

BACKGROUND The cyclin-dependent kinase inhibitor p27 plays important roles in cell proliferation, cell motility, and apoptosis. Interestingly, the nuclear and cytoplasmic p27 exert opposite biological functions. In this study, we investigated the prognostic impact of subcellular p27 expression. METHODS We constructed melanoma tissue microarrays in a large series of melanoma patients, includin...

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