FCS 840 Community, Societal, and International Research 3(3,0) Covers issues and methods of community, societal, and international research and evaluation; macro-level assessment of the impact of interventions and the documentation of change; multi-method etic and emic strategies, theory-based evaluation, longitudinal designs, and collaborative, consultative models of research. Preq: PSYCH 810,...

PHIL 625 Philosophy of Psychology 3(3,0) Detailed examination of psychology as an autonomous science. Issues include explanation in psychology and cognitive neuroscience, psychology naturalized as a “special science” comparable to biology and geology, evolutionary psychology, philosophy and psychopathology, and moral issues in psychology. Preq: Nine hours of psychology or consent of instructor....

Archaeosine (G(+)) is found at position 15 of many archaeal tRNAs. In Euryarchaeota, the G(+) precursor, 7-cyano-7-deazaguanine (preQ(0)), is inserted into tRNA by tRNA-guanine transglycosylase (arcTGT) before conversion into G(+) by ARChaeosine Synthase (ArcS). However, many Crenarchaeota known to harbor G(+) lack ArcS homologues. Using comparative genomics approaches, two families that could ...

QueF enzymes catalyze the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ₀) to 7-aminomethyl-7-deazaguanine (preQ₁) in the biosynthetic pathway to the tRNA modified nucleoside queuosine. The QueF-catalyzed reaction includes formation of a covalent thioimide intermediate with a conserved active site cysteine that is pro...

Reuse of approved software components has been identified as one of the key factors for successful software engineering projects. Although the reuse process also covers many non-technical aspects [9] we will restrict ourselves to the retrieval of software components (SCR) based on their formal specifications. Our system NORA/HAMMR 3 is based on a library of software components with associated s...

C E 860 Advanced Fluid Mechanics 3(3,0) Laminar and turbulent flows; boundary layer and free shear flows (jets, wakes, etc.); descriptions of velocity, shear stress and pressure measurements, and aerodynamic drag. C E 861 Mechanics of Sediment Transport 3(3,0) Characterization of sediments; physical principles governing fluvial, estuarial, and coastal transport of cohesionless and cohesive sedi...

The enzyme tRNA-guanine transglycosylase (TGT) is involved in the queuosine modification of tRNAs in eukarya and eubacteria and in the archaeosine modification of tRNAs in archaea. However, the different classes of TGTs utilize different heterocyclic substrates (and tRNA in the case of archaea). Based on the X-ray structural analyses, an earlier study [Stengl et al. (2005) Mechanism and substra...

8-10 A better understanding of the effects that oxidative lesions have on RNA is of importance to understand their role in the development/progression of disease. 8-oxo-7,8-dihydroguanine was incorporated into RNA to understand its structural and functional impact on RNA:RNA and RNA:DNA duplexes, hairpins and pseudoknots. One to three modifications were incorporated into dodecamers of RNA [AAGA...

N-acetylquinovosamine (2-acetamido-2,6-di-deoxy-D-glucose, QuiNAc) is a relatively rare amino sugar residue found in glycans of few pathogenic gram-negative bacteria where it can play a role in infection. However, little is known about QuiNAc-related polysaccharides in gram-positive bacteria. In a routine screen for bacillus glycan grown at defined medium, it was surprising to identify a QuiNAc...

This paper describes work undertaken by the Graduate Careers Council of Australia (GCCA) in conducting the pilot Postgraduate Research Experience Questionnaire (PREQ). This questionnaire explores the experience of higher degree research graduates, aspects of whose university careers have not been examined previously on a national basis. Two versions of the pilot survey have been developed in th...