نتایج جستجو برای: prenylation

تعداد نتایج: 805  

Journal: :Eukaryotic cell 2013
Ruth Howe Megan Kelly John Jimah Dana Hodge Audrey R Odom

The antimalarial agent fosmidomycin is a validated inhibitor of the nonmevalonate isoprenoid biosynthesis (methylerythritol 4-phosphate [MEP]) pathway in the malaria parasite, Plasmodium falciparum. Since multiple classes of prenyltransferase inhibitors kill P. falciparum, we hypothesized that protein prenylation was one of the essential functions of this pathway. We found that MEP pathway inhi...

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Journal: :The Cardinal edge 2021

Protein prenylation is the addition of a 15 or 20 carbon lipid to cysteine near carboxyl terminus target proteins. Prentlyation increases hydrophobicity, which facilitates membrane associations and protein-protein interaction. generally conserved among eukaryotes, mutations in genes that carry out are lethal animals yeast. In plants not always lethal, but they do affect development, disease res...

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Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Amany Mohamed Lucila Saavedra Alba Di Pardo Simonetta Sipione Elena Posse de Chaves

Accumulation of β-amyloid (Aβ) inside brain neurons is an early and crucial event in Alzheimer's disease (AD). Studies in brains of AD patients and mice models of AD suggested that cholesterol homeostasis is altered in neurons that accumulate Aβ. Here we directly investigated the role of intracellular oligomeric Aβ(42) (oAβ(42)) in neuronal cholesterol homeostasis. We report that oAβ(42) induce...

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Journal: :The Journal of biological chemistry 2001
N H Thomä A Iakovenko R S Goody K Alexandrov

Rab geranylgeranyltransferase (RabGGTase or GGTase-II) catalyzes the post-translational prenylation of Rab proteins. Rab proteins are recognized as substrates only when they are complexed to Rab Escort Protein (REP). The classical model of prenylation complex assembly assumes initial formation of the Rab.REP binary complex, which subsequently binds to RabGGTase loaded with the isoprenoid donor ...

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Journal: :Molecular cancer therapeutics 2002
Robert B Lobell Dongming Liu Carolyn A Buser Joseph P Davide Elizabeth DePuy Kelly Hamilton Kenneth S Koblan Yih Lee Scott Mosser Sherri L Motzel James L Abbruzzese Charles S Fuchs Eric K Rowinsky Eric H Rubin Sunil Sharma Paul J Deutsch Kathryn E Mazina Briggs W Morrison Lynne Wildonger Siu-Long Yao Nancy E Kohl

Farnesyl:protein transferase (FPTase) inhibitors were developed as anti-Ras drugs, but they fail to inhibit Ki-Ras activity because Ki-Ras can be modified by geranylgeranyl:protein transferase type-I (GGPTase-I). L-778,123, an inhibitor of FPTase and GGPTase-I, was developed in part because it can completely inhibit Ki-Ras prenylation. To support the clinical development of L-778,123, we develo...

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Journal: :The Biochemical journal 1998
A L Wilson R A Erdman F Castellano W A Maltese

Rab GTPases are post-translationally modified by addition of geranylgeranyl moieties to carboxyl-terminal cysteine residues. For Rab proteins ending with xxCC xCxC and CCxx motifs this modification is catalysed by geranylgeranyltransferase type II (GGTaseII), and is entirely dependent on the Rab substrate being bound to Rab escort protein (REP). Several Rab proteins contain carboxyl-terminal Ca...

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Journal: :Biochemical and biophysical research communications 2017
Peng Peng Wei Wei Cheng Long Jingwen Li

Ras signaling is often dysregulated and plays essential roles for the maintenance of glioblastoma. The proper function of Ras depends largely on the appropriate post-translational modification termed prenylation. Targeting protein prenylation therefore represents an alternative therapeutic strategy in glioblastoma. In this study, we demonstrate that prenylation inhibition by atorvastatin is act...

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Journal: :Molecular bioSystems 2011
Guillaume Charron Lun K Tsou William Maguire Jacob S Yount Howard C Hang

Protein S-prenylation is a lipid modification that regulates membrane-protein and protein-protein interactions in cell signaling. Though sites of protein S-prenylation can be predicted based upon conserved C-terminal CaaX or CC/CXC motifs, biochemical detection of protein S-prenylation in cells is still challenging. Herein, we report an alkynyl-isoprenol chemical reporter (alk-FOH) as an effici...

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Journal: :Plant physiology 2011
Nadav Sorek Orit Gutman Einat Bar Mohamad Abu-Abied Xuehui Feng Mark P Running Efraim Lewinsohn Naomi Ori Einat Sadot Yoav I Henis Shaul Yalovsky

Prenylation primarily by geranylgeranylation is required for membrane attachment and function of type I Rho of Plants (ROPs) and Gγ proteins, while type II ROPs are attached to the plasma membrane by S-acylation. Yet, it is not known how prenylation affects ROP membrane interaction dynamics and what are the functional redundancy and specificity of type I and type II ROPs. Here, we have used the...

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Journal: :Chinese Journal of Catalysis 2021

C2 prenylated indoles are widespread in a variety of bioactive natural alkaloids. Therefore, the selective installation prenyl group at position NH is great significance. However, known protocols generally require multi-step procedure and stoichiometric promoters. Herein we develop one-step prenylation indole with cheap tert-prenyl alcohol enabled by acid catalysis. Salient features include goo...

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  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->