N Engl J Med 2009;360:2328-39. Copyright © 2009 Massachusetts Medical Society. A drenal insufficiency — the clinical manifestation of deficient production or action of glucocorticoids — is a life-threatening disorder that may result from either primary adrenal failure or secondary adrenal disease due to impairment of the hypothalamic–pituitary axis.1,2 This article focuses on providing the prac...