Background& Objective: Each laboratory should determine the type of errors and turnaround time (TAT), especially in the preanalytical phase to report quality and timeliness of the test results. The current study aimed at investigating the common causes of preanalytical errors in biochemistry and hematology laboratories and evaluating the preanalytical ...

OBJECTIVE To collect and tabulate errors and nonconformities in the preanalytical, analytical, and postanalytical process phases in a diagnostic clinical laboratory that supports a super-specialty cancer center in India, and identify areas of potential improvement in patient services. METHODS We collected data from our laboratory during a period of 24 months. Departments in the study included...

Clinical trials and epidemiologic and most types of clinical research include the acquisition of biological samples to be analyzed either immediately after collection or in the future for biomarkers related to the study hypotheses. Tested biomarkers include those used to monitor subjects’ health and to detect harmful side effects (e.g., liver and kidney function tests) or to follow the impact o...

Preanalytical uncertainty is attributable to variations in blood sample collection and sample handling before analysis. The aim of this study was to establish a modelling framework for estimating preanalytical uncertainty. There is a need for standardization on which uncertainty sources that should be included, and how the preanalytical uncertainty should be estimated. In Paper I, an uncertaint...

BACKGROUND Most errors in a clinical chemistry laboratory are due to preanalytical errors. Preanalytical variability of biospecimens can have significant effects on downstream analyses, and controlling such variables is therefore fundamental for the future use of biospecimens in personalized medicine for diagnostic or prognostic purposes. CONTENT The focus of this review is to examine the pre...

Urine may be a waste product, but it contains an enormous amount of information. Well-standardized procedures for collection, transport, sample preparation and analysis should become the basis of an effective diagnostic strategy for urinalysis. As reproducibility of urinalysis has been greatly improved due to recent technological progress, preanalytical requirements of urinalysis have gained im...

In the 70ies of the last century, ther term "preanalytical phase" was introduced in the literature. This term describes all actions and aspects of the "brain to brain circle" of the medical laboratory diagnostic procedure happening before the analytical phase. The author describes his personal experiences in the early seventies and the following history of increasing awareness of this phase as ...

Laboratory diagnostics develop through different phases that span from test ordering (pre-preanalytical phase), collection of diagnostic specimens (preanalytical phase), sample analysis (analytical phase), results reporting (postanalytical phase) and interpretation (post-postanalytical phase). Although laboratory medicine seems less vulnerable than other clinical and diagnostic areas, the chanc...