The primary goal of this study was to determine whether exercise-associated improvements of the immune response to influenza vaccination were mediated by improvements in psychosocial factors in older adults. At baseline, prior to the exercise intervention, older adult participants were immunized with influenza vaccine. Blood samples collected pre-immunization, 1, 4, and 12 weeks post-immunizati...

Pre-erythrocytic malaria vaccines, including those based on whole-parasite approaches, have shown protective efficacy in animal and human studies. However few pre-erythocytic antigens other than the immunodominant circumsporozoite protein (CSP) have been studied in depth with the goal of developing potent subunit malaria vaccines that are suited for use in endemic areas. Here we describe a nove...

The practice of aspiration before administering intramuscular immunization has been identified as causing increased pain. The latest evidence shows that this is no longer best practice. Some nurses believe that aspiration is necessary for patient safety. An education session was provided to 150 participants, most of whom were community health nurses attending an immunization conference. Nurses ...

Limited antifungal drugs, their high toxicity, and the emergence of resistant Candida albicans strains indicate the need for novel therapeutic strategies. The objectives of this study were to prepare antibodies against C albicans in an egg-laying hen and evaluate the efficacy of these antibodies in preventing the dissemination of C albicans in BALB/c mice. An egg-laying hen was immunized with a...

OBJECTIVE Invasive pneumococcal disease is a major cause of death in HIV-infected children. The objective of the study was to assess the quantitative antibody response to the seven pneumococcal serotypes of heptavalent pneumococcal conjugate vaccine in a group of HIV-infected children. METHODS Study comprising 40 HIV-infected children aged between 2 and 9 years followed up in a specialized ou...

OBJECTIVE To assess the knowledge, attitude and practices of general practitioners regarding tetanus immunization in adults. SETTING The study was conducted in District Central, Karachi. STUDY DESIGN This was a Knowledge, Attitude and practices (KAP) survey. METHODS From a list of 1050 general practitioners (GPs), 100 were selected through simple random sampling and interviewed through a ...

OBJECTIVES Canada's progress in establishing a national immunization registry and coordinated immunization schedule across provinces has been slow. The absence of a centralized registry means there are only limited data available on childhood immunization coverage in Canada. The aim of this study was to estimate the completeness and timeliness of immunization for two year-old children in Nova S...

OBJECTIVE Our studies aimed to measure the quality of antibody response to influenza vaccines in the elderly. The frequency of significant rise in hemagglutination inhibition (HAI) titer in the elderly is low and although annual vaccination reduces morbidity and mortality, better correlates of vaccine efficacy in the elderly are needed. METHODS We measured the amount and avidity of serum anti...