Peroxisome proliferator-activated receptor-alpha (PPARA) has been shown to increase fatty acid oxidation and decrease cytokine levels and has been implicated in insulin production. Genetic variants of PPARA have been associated with cardiovascular disease, obesity and type II diabetes mellitus. Although no research to date has investigated the possible link between PPARA and breast cancer, the ...

Carlsson, Linda, Daniel Lindén, Masoumeh Jalouli, and Jan Oscarsson. Effects of fatty acids and growth hormone on liver fatty acid binding protein and PPARa in rat liver. Am J Physiol Endocrinol Metab 281: E772–E781, 2001.—The aim of this study was to investigate the interaction between long-chain fatty acids (LCFA) and growth hormone (GH) in the regulation of liver fatty acid binding protein (...

The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. PPAR\(\alpha\) deficiency in inflammatory cells suppresses tumor growth. PLoS ONE 2(2): e260. Inflammation in the tumor bed can either promote or inhibit tumor growth. Peroxisome proliferator-activated receptor (PPAR)a is a central transcriptional suppressor of inflammati...

The peroxisome proliferator-activated reccptora (PPARa) is the mediator of the biological effects of pcroxisome proliferators through control of gene transcription. To determine if the toxic effects of di(2-ethylhexy1)phthalate (DEHP) are mediated by PPARa, we examined its effect in PPARa-null micc. Male Sv1129 mice. PPARa-null (-/-) or wild-typc (+I+) were fed nd libirirrn either a control die...

Peroxisome proliferator–activated receptor alpha (PPARa) is a member of the nuclear factor PPAR family that regulates a variety of cellular functions, including lipid metabolism, cellular oxidative stress defense, and inflammatory responses. Based on the report that Wy14,643, a PPARa agonist, can upregulate uncoupling protein-2 (UCP-2), this study was conducted in primary cortical cells to dete...

Minnich, Anne, Nian Tian, Lisa Byan, and Glenda Bilder. A potent PPARa agonist stimulates mitochondrial fatty acid b-oxidation in liver and skeletal muscle. Am J Physiol Endocrinol Metab 280: E270–E279, 2001.—The proposed mechanism for the triglyceride (TG) lowering by fibrate drugs is via activation of the peroxisome proliferator-activated receptor-a (PPARa). Here we show that a PPARa agonist,...

Peroxisome proliferator-activated receptor α (PPARα) is a transcription factor that regulates lipid and glucose metabolism. Accumulating evidence suggests that the intron 7 C allele of the PPARA gene rs4253778 G/C polymorphism has an advantage for power-oriented athletes, presumably due to the hypertrophic effects on skeletal muscle and increase in glucose utilization in response to anaerobic e...

We have recently demonstrated that troglitazone exerts an antiinflammatory effect in the insulin resistant obese in vivo in parallel with its insulin-sensitizing effect. Because these effects are thought to be mediated through peroxisome proliferator-activated receptors a and g (PPARa and PPARg), we have now examined the possibility that troglitazone may modulate the expression of PPARa and PPA...

RNA interference (RNAi) has great potential as a tool for studying gene function in mammals. However, the specificity and magnitude of the in vivo response to RNAi remains to be fully characterized. A molecular and phenotypic comparison of a genetic knockout mouse and the corresponding knockdown version would help clarify the utility of the RNAi approach. Here, we used hydrodynamic delivery of ...

PPARg and PPARd) are a set of ligand-activated transcription factors in the nuclear hormone receptor superfamily. These receptors regulate the expression of a large number of genes involved in lipid metabolism and energy balance by binding to a DNA sequence termed PPAR response elements. The PPARg is predominantly expressed in adipose tissues, and plays a pivotal role in adipose differentiation...