Introduction: Post-traumatic seizures can occur as a complication of head injury, whether it is immediately after the injury to months or years after. Phenytoin an anti-epileptic drug that has been used widely prophylaxis for posttraumatic seizures. Method: The study was conducted retrospectively using medical records trauma patients in hospitals 2020-2022 on 54 samples treated up seven days po...

Epidemiological data support a link between traumatic brain injury (TBI) and seizures. TBI accounts for approximately 16 % of acute symptomatic seizures which usually occur in the first week after trauma. Children are at higher risk for posttraumatic seizures than adults and experience greater morbidity and mortality from cerebral edema (CE). CE is responsible for half of the mortality associat...

Posttraumatic epilepsy is a major source of disability following traumatic brain injury (TBI) and a common cause of medically-intractable epilepsy. Previous attempts to prevent the development of posttraumatic epilepsy with treatments administered immediately following TBI have failed. Recently, the mammalian target of rapamycin complex 1 (mTORC1) pathway has been implicated in mechanisms of ep...

BACKGROUND Posttraumatic seizure (PTS) is a significant complication of traumatic brain injury (TBI). OBJECTIVE To perform a systematic review and meta-analysis to compare levetiracetam with phenytoin for seizure prophylaxis in patients diagnosed with severe TBI. METHODS An inclusive search of several electronic databases and bibliographies was conducted to identify scientific studies that ...

Human posttraumatic epilepsy (PTE), the most common acquired epilepsy in teenagers and young adults, is an unfortunate natural experiment that may provide insight into epileptogenesis and antiepileptogenic interventions. In PTE, epilepsy develops weeks to months after traumatic brain injury (TBI), and often in a previously nonepileptic and otherwise healthy brain. Particularly in severe TBI, th...

Gliosis is a pathological hallmark of posttraumatic epileptic foci, but little is known about these reactive astrocytes beyond their high glial fibrillary acidic protein (GFAP) expression. Using diolistic labeling, we show that cortical astrocytes lost their nonoverlapping domain organization in three mouse models of epilepsy: posttraumatic injury, genetic susceptibility, and systemic kainate e...

OBJECTIVES According to recent findings trauma and stress are important etiological factors in pathogenesis of depression. As characteristic features of depressive cognition have been reported intrusive thoughts and memory disturbances similar to posttraumatic symptoms known in patients with posttraumatic stress disorder or dissociative disorders. Hypothetically is also suggested a close relati...