BACKGROUND Postoperative intra-abdominal adhesions are common complications after abdominal surgery. The exact molecular mechanisms that are responsible for these complications remain unclear, and there are no effective methods for preventing adhesion formation or reformation. The aim of the study reported here was to investigate the preventive effects and underlying potential molecular mechani...

objective: to determine the preventive effects of local administration of simvastatin for postoperative intra-abdominal adhesion formation in animal model of rat . methods: in this experimental study, 32 wistar albino rats as the animal model of intra-abdominal adhesion formation were included. adhesions were induced in all the animals via abrasion of the peritoneal and intestinal surface durin...

in our experimental study, 48 rats were divided into six groups in a randomized manner: a (1-3) and b (1-3) groups. a1 and b1 were negative controls. laparotomy was performed and peritoneal inflammation on exposed bowel and peritoneum in a (1-3) and experimental infection induced in peritoneal cavity of b (1-3). each rat of a2 and b2 received 100 iu intraperitoneal standard heparin and each rat...

Peritoneal adhesions represent an important clinical challenge in gastrointestinal surgery. Peritoneal adhesions are a consequence of peritoneal irritation by infection or surgical trauma, and may be considered as the pathological part of healing following any peritoneal injury, particularly due to abdominal surgery. The balance between fibrin deposition and degradation is critical in determini...

BACKGROUND Formation of intra-abdominal adhesions depends, in part, on the activity of serine proteinases. Matrix metalloproteinases (MMP) are required for epithelialization of skin wounds but their involvement in mesothelialization of peritoneal wounds and in adhesion pathogenesis is not known. Early tumor necrosis factor-alpha (TNF-alpha) levels have been proposed to reflect propensity to adh...

Fibrous adhesions remain a major sequela of abdominal surgery. The proinflammatory peptide substance P (SP), known to participate in inflammatory events, may play a key role in adhesion formation. This hypothesis was tested by using an antagonist, CJ-12,255 (Pfizer), that blocks the binding of SP to the neurokinin 1 receptor (NK-1R). Adhesion formation was surgically induced in the peritoneum o...

BACKGROUND Peritoneal lavage with saline at room temperature causes peritoneal hypothermia, vasoconstriction, hypoxia, and acidosis, which are effects that are known to reduce fibrinolysis. Decreased fibrinolysis causes permanent adhesions. Normothermic lavage may prevent this deleterious process and reduce peritoneal adhesions. METHODS A rat model of cecal abrasion was used. Control animals ...

Introduction Peritoneal adhesions have been reported as an adverse side effect of surgery for more than a century and occur in 90-100% of cases. Postoperative adhesion formation results from a series of local events at the trauma site. Peritoneal injury by surgery, infection, or irritation initiates a local inflammatory reaction, exudation, and fibrin deposition into which white blood cells; ma...

OBJECTIVES Adhesion formation continues to be an important problem in gastrointestinal surgery. In recent years, methylene blue (MB) has been reported to be an effective agent for preventing peritoneal adhesions. However, its effects on the wound healing process are unknown. In the present study, we investigated the effects of MB on the early and late phases of anastomotic wound healing and on ...