Recent advances in our understanding of plant metabolism have highlighted the significance specialized metabolites regulation gene expression associated with biosynthetic networks. This opinion article focuses on molecular mechanisms small-molecule-mediated feedback at transcriptional level and its potential modes action, including metabolite signal perception, nature sensor, signaling transduc...

Papillomavirus genomes are transcribed as one large complex transcription unit with multiple promoters, two poly(A) sites (early and late), and considerable alternative splicing. As a result, there are multiple opportunities for post-transcriptional regulation of papillomavirus gene expression. Although this area has not been as extensively studied as transcriptional regulation, there are a few...

The control of gene expression in articular chondrocytes is an essential factor in maintaining the homoeostasis of extracellular matrix synthesis and turnover necessary in healthy articular cartilage. Although much is known of how steady-state levels of gene expression and rates of transcription are altered, there has been a poorer understanding of gene control at the post-transcriptional level...

OF THE DISSERTATION ........................................................................... ii DEDICATION .................................................................................................................... v LIST OF FIGURES AND TABLES.................................................................................. ix ACKNOWLEDGMENTS ...........................................

Transcriptional regulation by transcription factors and post-transcriptional regulation by microRNAs constitute two major modes of regulation of gene expression. While gene expression motifs incorporating solely transcriptional regulation are well investigated, the dynamics of motifs with dual strategies of regulation, i.e., both transcriptional and posttranscriptional regulation, have not been...