This 66-year-old Iranian gentle man had a one-year history of asymptomatic keratotic papules with a linear distribution on the skin of his right palm near the wrist. On histopathologic examination-cornoid lamella-like parakeratotic columns above eccrine ducts were observed. The acrosyringium was also dilated. The diagnosis was porokeratotic eccrine ostial and dermal duct nevus. The late-onset d...

Sir, Porokeratotic eccrine ostial and dermal duct naevus (PEODDN) is a rare disorder of keratinization with eccrine involvement that histologically presents a cornoid lamella exclusively associated with eccrine ostia and the underlying sweat ducts (1). It is an expression of genetic mosaicism (2) and is characterized by asymptomatic grouped keratotic papules and plaques with a linear distributi...

Porokeratotic eccrine ostial and dermal duct nevus, or porokeratotic eccrine nevus (PEN), is a hyperkeratotic epidermal nevus. Several cases of widespread involvement have been reported, including one in association with the keratitis-ichthyosis-deafness (KID) syndrome (OMIM #148210), a rare disorder caused by mutations in the GJB2 gene coding for the gap junction protein connexin26 (Cx26). The...

Sir, Disseminated porokeratosis palmaris and plantaris (DPPP), a subtype of porokeratosis Mibelli, is a rare autosomal dominant genodermatosis first described by Guss et al. in 1971 (1). An early review of the literature showed that 7% of 250 patients with porokeratosis subsequently developed skin tumours (2). Squamous cell carcinomas (SCC), Bowen’s disease (BD), and rarely, basal cell carcinom...

Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is an uncommon, benign dermatosis and is characterized by asymptomatic grouped keratotic papules and plaques with a linear pattern on the extremities. Various treatments, including topical steroids, topical calcipotriol, topical 5-fluorouracil, retinoid, cryotherapy, and carbon dioxide laser ablation have been tried for PEODDN, but the...

be associated with porokeratosis,[8] this diagnosis was not considered owing to the lack of typical clinical features and histology of this condition. Authentic clinical and histologic features of Nekam’s disease are, respectively,[9] a facial seborrheic dermatitislike eruption with tiny confluent papules on the trunk and extremities in linear and reticulate arrays and an infundibulocentric and...