PURPOSE p27(Kip1) is a member of the Cip1/Kip1 family of cyclin-dependent kinase inhibitors and is a potential tumor suppressor gene. Low levels of p27 are associated with poor prognosis in a variety of gynecological tumors, including breast, ovarian, and cervical carcinomas. The role of p27 in endometrial cancer remains controversial. EXPERIMENTAL DESIGN In the present study, p27 protein exp...

CDCP1, a transmembrane protein with intracellular tyrosine residues which are phosphorylated upon activation, is supposed to be engaged in proliferative activities and resistance to apoptosis of cancer cells. High level of CDCP1 expression proved to be a poor prognosticator for lung adenocarcinoma. Here, expression level of CDCP1 was immunohistochemically examined in 110 cases (median age of 54...

Endometrial hyperplasia is thought to be caused by the prolonged, unopposed oestrogenic stimulation of the endometrium. The regression of hyperplastic back to normal endometrium is the main purpose of any conservative treatment in order to prevent development of adenocarcinoma. The aim of this study was to evaluate the regression of hyperplastic to normal endometrium in patients with various fo...

Intrauterine adhesions (IUA) frequently occur after infectious or mechanical injury to the endometrium, which may lead to infertility and/or pregnancy complications. There are few effective treatments due to the complex function of endometrium and shortage of native materials. 17β-estradiol (E2) is commonly used as an ancillary treatment in IUA patients, but it is limited by its poor solubility...

OBJECTIVE Serous papillary carcinomas of the endometrium are aggressive tumors that tend to permeate, in a very extensive fashion, to uterine and adnexal lymphatic and vascular channels at an early stage in their evolution, and are associated with a particularly gloomy prognosis. It is generally thought that even tumors apparently limited to the endometrium or confined to an endometrial polyp h...

Patients with breast cancer exhibit an increased risk in developing neoplasms of other organs. In case of endometrium, the increased risk might be due to tamoxifen adjuvant therapy and prior radiotherapy. Carcinosarcomas are rare uterine cancers and carry poor prognosis. We present a case of Malignant Mixed Mullerian Tumor (MMMT) of the uterus in a 46-year-old woman, after tamoxifen treatment a...

AIMS Musashi-1, a RNA-binding protein, is suggested to be a cancer stem cell-related marker; its high level of protein expression is reported to be associated with high histological grade in some tumors. The aim of this study was to investigate the prognostic value of Musashi-1 in patients with endometrioid adenocarcinoma (EAC). METHODS We examined the Musashi-1 mRNA expression level in 35 fr...

Endometriosis is a common disease of women. In the present study, the expression of osteopontin (OPN), integrin αvβ3 and vascular endothelial growth factor (VEGF) in tissue of endometriosis were studied in order to investigate their functions and the clinical value. The result of the present study revealed that OPN was expressed in the gland epithelium cells, and the expression of OPN in ectopi...

Endometrial carcinoma (EC), the second most common form of gynaecological malignancy, can be divided into two distinct sub-types: Type I tumours arise from hyperplastic endometrium and typically effect women around the time of menopause, whereas type II tumours arise in postmenopausal women from atrophic endometrium. Long non-coding RNAs (lncRNAs) are a novel class of non-protein coding molecul...

To investigate the effects of the frozen embryo transplantation for patients with poor outcome of endometrial growth by using growth hormone intrauterine perfusion combined with replacement cycle in the treatment of non-response thin endometrium. This is a prospective study and study participants were consecutively recruited between Jun 2014 and December 2014. A total of 5 non-response thin end...