نتایج جستجو برای: polysialylated neural cell adhesion molecule psa

تعداد نتایج: 2071506  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1998
T Ben-Hur B Rogister K Murray G Rougon M Dubois-Dalcq

Oligodendrocyte-type 2 astrocyte (O-2A) lineage cells are derived from multipotential stem cells of the developing CNS. Precursors of O-2A progenitors express the polysialylated (PSA) form of the neural cell adhesion molecule (NCAM) and are detected in neonatal rat brain glial cultures. It is unclear how such PSA-NCAM+ "pre-progenitors" are related to neural stem cells and whether they still ha...

Journal: :FEBS letters 2014
Xiaodong Li Amit R L Persad Elizabeth A Monckton Roseline Godbout

The AP-2δ transcription factor is restricted to a subset of retinal ganglion cells. Overexpression of AP-2δ in chick retina results in induction of polysialylated neural cell adhesion molecule (PSA-NCAM) accompanied by misrouting and bundling of ganglion cell axons. Two polysialyltransferases, ST8SIA2 and ST8SIA4, are responsible for polysialylation of NCAM. Here, we investigate the mechanism d...

Journal: :The international journal of neuropsychopharmacology 2008
Angelisa Frasca Fabio Fumagalli Judith Ter Horst Giorgio Racagni Keith J Murphy Marco A Riva

Repeated antipsychotic treatment may produce adaptive changes ranging from cytoarchitectural rearrangements to synaptic modifications that might contribute to clinical improvement. We performed a prolonged treatment (2 wk) with the first-generation antipsychotic (FGA) haloperidol (1 mg/kg) and the second-generation antipsychotic (SGA) olanzapine (2 mg/kg twice daily) and analysed the expression...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
F Bouzioukh F Tell A Jean G Rougon

Here we report that synapses in the adult dorsal vagal complex, a gateway for many primary afferent fibers, express a high level of the polysialylated neural cell adhesion molecule (PSA-NCAM). We show that electrical stimulation of the vagal afferents causes a rapid decrease of PSA-NCAM expression both in vivo and in acute slices. Inhibition of NMDA receptor activity completely prevented the de...

2015
Feng Guan Xin Wang Fa He

Neural cell adhesion molecule 140 (NCAM-140) is a glycoprotein and always highly polysialylated in cancer. Functions of polysialic acid (PSA) that binds to N-glycan termini on NCAM remain unclear. ldlD-14 cells, a CHO cell mutant deficient in UDP-Gal 4-epimerase, are useful for structural and functional studies of Gal-containing glycoproteins because their abnormal glycosylation can be converte...

Journal: :acta medica iranica 0
ali razmi department of pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. mousa sahebgharani department of pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. mohammad hossein khani department of pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. seyed hassan paylakhi department of biology, faculty of medicine, damghan university of medical sciences, damghan, iran. mehrdad faizi department of pharmacology and toxicology, faculty of pharmacy, shahid beheshti university of medical sciences, tehran iran. mohammad-reza zarrindast department of pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran.

neural cell adhesion molecules (ncams) are known to influence memory by affecting neural cell-cell and cell-extracellular matrix junctions. this study investigated the possible role of camp pathway in the expression of hippocampal ncam and its polysialylated derivative (psa-ncam). the following pharmacological tools were employed for manipulation of camp pathway: a) forskolin; the activator of ...

Journal: :Cerebral cortex 2011
María Ángeles Gómez-Climent Ramón Guirado Esther Castillo-Gómez Emilio Varea María Gutierrez-Mecinas Javier Gilabert-Juan Clara García-Mompó Sandra Vidueira David Sanchez-Mataredona Samuel Hernández José Miguel Blasco-Ibáñez Carlos Crespo Urs Rutishauser Melitta Schachner Juan Nacher

Principal neurons in the adult cerebral cortex undergo synaptic, dendritic, and spine remodeling in response to different stimuli, and several reports have demonstrated that the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) participates in these plastic processes. However, there is only limited information on the expression of this molecule on interneurons and on its role ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
H S Keirstead T Ben-Hur B Rogister M T O'Leary M Dubois-Dalcq W F Blakemore

Transplantation offers a means of identifying the differentiation and myelination potential of early neural precursors, features relevant to myelin regeneration in demyelinating diseases. In the postnatal rat brain, precursor cells expressing the polysialylated (PSA) form of the neural cell adhesion molecule NCAM have been shown to generate mostly oligodendrocytes and astrocytes in vitro (Ben-H...

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