Since Coley and Stewart (1945) recorded two cases of sarcomatous change in polyostotic fibrous dysplasia, there have been a further twelve reported cases ofmalignant change occurring in patients with fibrous dysplasia (Table I). Eight ofthese occurred in patients with polyostotic fibrous dysplasia and, of these, three were in patients with Albright’s syndrome. Of the other six patients, in five...

Fibrous dysplasia is a condition leading to abnormal differentiation of osteoblasts which leads to replacement of normal bone with fibrous stroma [1-3]. It may involve single bone (monostotic) or multiple bones (polyostotic). It may affect any bone however; skull and ribs are the commonest [2,4-6]. It is usually asymptomatic and is an incidental finding. It may become symptomatic when complicat...

An 18-year-old man was referred to the authors' institution's thoracic cancer specialists for further consultation after abnormal findings were seen on chest radiograph.

Objective: To analyse the clinical characteristics and imaging findings of maxillofacial fibrous dysplasia and the relationship between serum alkaline phosphatase and its clinical relative factors. Method: The clinical materials of 72 fibrous dysplasia patients were reviewed and the alkaline phosphatase among monostotic fibrous dysplasia, polyostotic fibrous dysplasia and non-fibrous dysplasia ...

The McCune-Albright Syndrome (MAS) is a sporadic rare disease first described in 1936 by McCune and separately by Albright. MAS is characterized by a triad of physical signs: café-au-lait spots, polyostotic fibrous dysplasia and autonomous endocrine hyperfunction. MAS is predominantly observed in girls and is rarely reported in males. We report the case of a 9-year old boy with gonadotropin ind...

BACKGROUND Polyostotic fibrous dysplasia is a skeletal disease that results from somatic activating mutations in the gene GNAS in skeletal stem cells, leading to proliferation of immature osteogenic cells with replacement of normal marrow and bone with fibro-osseous tissue. Lesions may cause bone deformity or fracture. In the surgical care of polyostotic fibrous dysplasia, the role of grafting ...

fibrous dysplasia of the bone (fdb) is a common, genetic, developmental disorder with a benign course. fdb can be seen anywhere throughout the skeleton. it is usually asymptomatic and found incidentally on imaging studies that are performed for other purposes. although whole body 18 f-flourodeoxyglucose pet/ct (fdg pet/ct) is widely used in tumor imaging, infections and benign pathologies like ...