A novel compound, KS-505a was isolated from the culture broth of a strain identified as Streptomyces argenteolus A-2. The compound inhibited bovine brain Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase with an IC50 value (the concentration causing 50% inhibition) of 0.065 microM. The compound around that concentration had little or no effect on heart calmodulin-dependent and -...

The structural properties of a new cyclic phosphor amide have been investigated in three methods and four basis sets and results have been compared with experimental data by spss. The best level for this type compound is HF/6-31++G** and with considering to this result, at this level, hyper chem input as initial geometry have been evaluated.

The cyclic nucleotide phosphodiesterases (PDEs) are intracellular enzymes that catalyze the hydrolysis of 3,'5'-cyclic nucleotides, such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), to their corresponding 5'nucleotide monophosphates. These enzymes play an important role in controlling cellular concentrations of cyclic nucleotides and thus regulate a variet...

a new cyclic diarylheptanoid namely alnuheptanoid b (3), along with four known cyclic diarylheptanoids: myricanone (1), (+)-s-myricanol (2), myricanone 5-o--d-glucopyranoside (4), and (+)-s-myricanol 5-o--d-glucopyranoside (5) were isolated from the etoac fraction of alnus japonica steud (family: betulaceae) stem bark. their structures were established by different spectroscopic analyses, as ...

Air-dried, milled leaves of Knoxia corymbosa (220 gm) were extracted repeatedly with dichloromethane. After removal of solvent in vacuo, the CH2Cl2-solvent residue was fractionated by using hexane and ethyl acetate solvents. After fractionation, all fractions are submitted for NMR spectroscopy. Out of all fractions interesting fractions are subjected to column chromatography, so that we isolate...

This study addresses whether pathological levels of cyclic strain activate the c-Myc promoter, leading to c-Myc transcription and downstream gene induction in human umbilical vein endothelial cells (HUVEC) or human aortic endothelial cells (HAEC). mRNA and protein expression of c-Myc under physiological (6-10%) and pathological cyclic strain conditions (20%) were studied. Both c-Myc mRNA and pr...

A "one bead two compound" approach to the synthesis of encoded cyclic peptoid libraries is reported.

Addition, together with antigen, of compound I.C.I. 74917 (0.1 pg/ml) to chopped sensitized lung, preincubated with DL-isoprenaline for 3 min, resulted in extra inhibition of histamine release as seen in Fig. 2(a). Comparison of the total inhibition with individual values for compound I.C.I. 74917 and isoprenaline show that there is addition rather than synergism, i.e. if compound I.C.I. 74917 ...