Chondroitin sulphate (CS) is a glycosaminoglycan widely distributed in animal tissues, which has anti-inflammatory and chondroprotective properties. We reported previously that chondroitin 4-sulphate (CS-A) up-regulates the antigen-specific Th1 immune response of murine splenocytes sensitized with ovalbumin in vitro, and that CS suppresses the antigen-specific IgE responses. We now demonstrate ...

The apparent molar volumes (?v) and viscosity B coefficients (Jones Dole)for Magnesium sulphate, Aluminium ammonium sulphate Potassium aluminium in aqueous Dimethylformamide (DMF) Dimethyl sulphoxide (DMSO) were evaluated from density (?) (?) at various temperatures as 308.15, 313.15, 318.15 323.15K with help of bicapillary pycnometer Ubbelohde viscometer instruments respectively. densitydata f...

Chondroitin sulphate proteoglycans are expressed in a temporally restricted pattern from embryonic day 17 to postnatal day 0 in both the thalamus and the cortical subplate, to which thalamic neurones transiently project. To study whether chondroitin sulphate proteoglycans could be specifically involved in the modulation of thalamic axon outgrowth, we compared neurite outgrowth from cultured rat...

This paper describes the details of the identification and determination of tyrosine 0-sulphate in fibrinogen, fibrin and fibrinopeptide B, as already reported in preliminary communications by the author under his previous names (Bettelheim, 1954; Bettelheim-Jevons, 1958). The first indication of the presence of tyrosine in modified form came during work on the peptides liberated from bovine fi...

Heparan sulphate and dermatan sulphate have both antithrombotic and anticoagulant properties. These are, however, significantly weaker than those of a comparable amount of standard pig mucosal heparin. Antithrombotic and anticoagulant effects of glycosaminoglycans depend on their ability to catalyse the inhibition of thrombin and/or to inhibit the activation of prothrombin. Since heparan sulpha...

AIM To characterise the distribution of major growth plate proteoglycans in a group of infants who died of SIDS. METHODS Nine such infants and eight age matched controls were selected from the necropsy files at the Adelaide Children's Hospital. Sections of rib and adjacent costal cartilage were stained for chondroitin-4-sulphate, chondroitin-6-sulphate, and keratan sulphate with antibodies 2-...

Two bio salt minerals, potassium sulphate, sodium sulphate and a mixture of both bio salts at the effective concentration of 1% which were added to the mulberry leaves of silkworm B. mori L., to evaluate their effect on the differential haemocyte counts (DHC) and absolute differential haemocyte counts (ADHC). Daily changes of five haemocyte types were investigated as, prohaemocytes, plasmatocyt...

The purification and properties of a hyaluronate lyase secreted by Streptococcus agalactiae, which is believed to facilitate the invasion of host tissues by the organism, have been described previously [Pritchard, Lin, Willingham and Baker (1994) Arch. Biochem. Biophys. 315, 431-436]. The specificity of the limited cleavage of chondroitin sulphate by the enzyme is the subject of this report. To...

The secretory enzyme extracellular superoxide dismutase (EC-SOD) occurs in at least three forms, which differ with regard to heparin affinity: A lacks affinity, B has intermediate affinity, and C has relatively strong affinity. The affinity of EC-SOD C for various sulphated glycosaminoglycans (GAGs) was assessed (a) by determining the concentration of NaCl required to release the enzyme from GA...