نتایج جستجو برای: polymorphic hla class i and ii
تعداد نتایج: 17216018 فیلتر نتایج به سال:
BACKGROUND The level of HLA expression on a tumour may influence the immunological response against this tumour, and vice versa. HLA expression was determined in a primary uveal melanoma, its metastases, and on a cell line derived from this melanoma, and the presence and type of infiltrate in tissue sections were also studied. METHODS Immunohistochemistry with monoclonal antibodies (MAbs) aga...
The human major histocompatibility complex HLA is located on the short arm of chromosome 6. It is known to be the most polymorphic genetic system in humans. The biological role of the HLA class I and class II molecules is to present processed peptide antigens. The HLA system is clinically important as transplantation antigens. Molecular HLA allele typing is routinely performed to provide HLA cl...
We have conducted an extensive phylogenetic analysis of polymorphic alleles from human and mouse major histocompatibility complex (MHC) class I and class II genes. The phylogenetic tree obtained for 212 complete human class I allele sequences (HLA-A, -B, and -C) has shown that all alleles from the same locus form a single cluster, which is highly supported by bootstrap values, except for one HL...
The human major histocompatibility complex class II antigens of the HLA-D are highly polymorphic, surface proteins essential in the cellular interactions necessary for an immune response. The analysis of this polymorphism is crucial for (i) histocompatibility matching for transplantation and (ii) understanding the association between HLA-D and certain important diseases. The polymorphism of cer...
ABSTRACT Natural Killer cells (NKs), are considered an important first line of defence and were originally defined by their ability to kill certain tumor cells and virally infected cells. Our aim is to study expression of HLA class-Ia on tumor cell lines and their susceptibility of NK cells. In this study MDA-MB-468 tumor cell line (NCB1, C208) That derived from human breast adenocarcino...
AIM The research was conducted by genotyping two Human Leukocyte Antigen (HLA) gene classes. The main objective of this research was to investigate distribution and frequency of the allelic groups, genotypes and haplotypes in the gene loci of HLA class I (HLA-A*, -B*, -C*) and HLA class II (HLA-DRB1*, -DQB1*) in patients included in the program of cadaveric renal transplantation. MATERIAL AND...
common variable immunodeficiency (cvid) is a heterogeneous heritable disease characterized by arrest in b cell differentiation. an association between cvid and two hla haplotypes, haplotype i (hla-a1, hla-b8, hla-dr3) and haplotype ii (hla-a29, hla-b44, hladr7)has been previously documented. in the present study, we have attempted to find an association between susceptibility to cvid and hla cl...
binding motifs of major histocompatibility complex (MHC) proteins, originally discovered by pool sequencing of MHC class I-bound peptides1, provide a biochemical basis for the phenomenon of MHC restriction of T-cell responses. However, the analysis of class II peptide motifs has proved difficult due to the heterogeneity in peptide length2–4. This problem has been overcome using several approach...
دراین مطالعه از سفالومتری lateral مربوط به " 38 " کودک دارای مال اکلوژنclass iii, class ii , class i که قبلا " تحت درمان قرار نگرفته اند، استفاده شده است . دربررسی سفالومتری و تجزیه و تحلیل نتایج آماری، اطلاعات زیر بدست آمد)1 : ارتباط بین زوایای saddle و sna معکوس بوده، اما تنها درگروه class iii ارتباط معنی دار و قوی است .)2 ارتباط بین زوایای saddle و snbنیز معکوس بوده، درگروه class ii و class ...
The HLA gene complex on human chromosome 6 is one of the most polymorphic regions in the human genome and contributes in large part to the diversity of the immune system. Accurate typing of HLA genes with short-read sequencing data has historically been difficult due to the sequence similarity between the polymorphic alleles. Here, we introduce an algorithm, xHLA, that iteratively refines the m...
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