Objectives We aimed to develop a sustained release system for an anti-TNFa drug in treatment of chronic inflammatory arthritis. A novel form of intra-articularly injectable etanercept (ETN) loaded poly(ε-caprolactone) (PCL) or methoxy poly(ethylene glycol)-poly(ε-caprolactone)methoxy poly(ethylene glycol) (MPEG-PCL-MPEG) microspheres (patent pending) were prepared to provide long term controlle...

objective(s): three-dimensional biomimetic scaffolds have widespread applications in biomedical tissue engineering due to similarity of their nanofibrous architecture to native extracellular matrix. co-culture system has stimulatory effect on chondrogenesis of adult mesenchymal stem cells. this work presents a co-culture strategy using human articular chondrons and adipose-derived stem cells (a...

introduction: the native inability of nervous system to regenerate, encourage researchers to consider neural tissue engineering as a potential treatment for spinal cord injuries. considering the suitable characteristics of induced pluripotent stem cells (ipscs) for tissue regeneration applications, in this study we investigated the adhesion, viability and proliferation of neural progenitors (de...

Recently, several thermogelling materials have been developed for biomedical applications. In this study, we prepared methoxy polyethylene glycol (MPEG)-b-(poly(ε-caprolactone)-ran-poly(2chloride-ε-caprolactone) (PCL-ran-PfCL)) (MP-Cl) diblock copolymers at room temperature via the ring-opening polymerization of caprolactone (CL) and 2-chloride-ε-caprolactone (fCL) monomers, using the terminal ...

The synthesis and properties of hybrid poly(ε-caprolactone) (PCL)–poly(ethylene oxide) (PEO) covalent adaptable networks have been investigated.

The adsorption of amphiphilic poly(ethylene oxide)-b-poly(epsilon-caprolactone) and poly(ethylene oxide)-b-poly(gamma-methyl-epsilon-caprolactone) copolymers in aqueous solution on silica and glass surfaces has been investigated by flow microcalorimetry, small-angle neutron scattering (SANS), surface forces, and complementary techniques. The studied copolymers consist of a poly(ethylene oxide) ...

Frontispiece 2: In article number 2000657 by Ericka Ford and co-workers, novel cyclic-poly(phthalaldehyde) blended poly(ε-caprolactone) fibers are wet spun to exhibit fast transience of less than 50 s when exposed daylight the mechanical strength stretch ability an elastomer. The rate is further improved embedding gold nanoparticles in fibers. Daylight-triggered among flexible has potential use...

The photodegradation of a 1:1 blend of poly (caprolactone) and poly(vinyl chloride) has been studied by following carbon dioxide emission during UV exposure. Similar measurements were made on poly(caprolactone) and poly(vinyl chloride) homopolymers prepared and irradiated in the same way. It was found that the blend gave lower CO2 emission than either of the two homopolymers, indicating that th...