We report the fabrication of carbohydrate microarrays on a photoactive polymer, poly(HEMA-co-HEMA-PFPA), synthesized by RAFT copolymerization of 2-hydroxyethyl methacrylate (HEMA) and perfluorophenyl azide (PFPA)-derivatized HEMA (HEMA-PFPA). PFPA allows the covalent immobilization of carbohydrates whereas the HEMA polymer provides an antifouling surface, thus the microarrays can be used direct...

With the advent of nanotechnology, the behavior of individual polymer chains is increasingly being studied due to their potential to act as molecular springs, switches, sensors, shock absorbers, and motors. Single molecule force spectroscopy (SMFS) or “tensile testing” is a powerful technique that is fast enabling rational nanomechanical design of synthetic polymers for such applications.1-3 Re...

Mul t iwa l led-carbon nanotubes (MWCNTs) were functionalized via thermoinitiated free radical polymerization of 2-hydroxyethyl methacrylate (HEMA) using benzoy l pe r ox i de . T ip son i ca t i on was used dur ing the polymerization reaction to separate agglomerated nanotubes. The functionalization was confirmed by control experiments and attenuated total reflectance Fourier transform infrare...

Abstract In this study, mesoporous silica nanoparticles (MSNs) were surface-modified with polymer poly(HEMA-co-PEGMA via surface-initiated atom transfer radical polymerization and a multifunctional nanoplatform MSNP@poly(HEMA-co-PEGMA-g-doxorubicin (DOX)/Rhodamine 6 G (R6G) was developed to combine photothermal (PTT) chemotherapy therapy effectively. PTT induced by near-infrared (NIR) radiation...

Immobilized metal chelate affinity chromatography (IMAC) support was practiced for α -amylase immobilization. Poly(hydroxyethylmethacrylate-methacryloylamidotryptophan)-Ni [p(HEMA-MAT)-Ni ] nanospheres, average diameter 100 nm, were produced by surfactant free emulsion polymerization. Characterizations of p(HEMAMAT)-Ni nanospheres were carried out by Fourier transform infrared (FTIR) spectrosco...

The strategy of phospholipid-based biomimicry has been used to molecularly engineer poly(2-hydroxyethyl methacrylate) [p(HEMA)]-based hydrogels for improved in vitro and potential in vivo biocompatibility. Two methacrylate-based monomers, poly(ethylene glycol) (200) monomethacrylate (PEGMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC), were incorporated at varying mole fractions of 0.0-0....

Bioactive films were produced by conjugation of a short peptide onto modified cellulose nanofibrils (CNF). Specifically, a hydrophilic copolymer, poly(2-aminoethyl methacrylate hydrochloride-co-2-hydroxyethylmethacrylate) (poly(AMA-co-HEMA)), was grafted via surface initiated polymerization from an initiator coupled to CNF. The poly(AMA-co-HEMA) was used as a spacer and support layer for immobi...

BACKGROUND Continuous glucose monitoring is crucial to developing a successful artificial pancreas. However, biofouling and host response make in vivo sensor performance difficult to predict. We investigated changes in glucose diffusivity and sensor response of optical enzymatic glucose sensors due to biological exposure. METHOD Three hydrogel materials, poly(2-hydroxyethyl methacrylate) (pHE...

We demonstrate the specificity, regenerability, and excellent storage stability of short peptide-based systems for detection of immunoglobulin G (IgG). The bioactive component consisted of acetylated-HWRGWVA (Ac-HWRGWVA), a peptide with high IgG binding affinity, which was immobilized onto copolymer matrixes of poly(2-aminoethyl methacrylate hydrochloride-co-2-hydroxyethyl methacrylate) (poly(A...

This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from copolymer poly(methyl methacrylate (MMA) and 2-hydroxyethyl (HEMA)) different monomer ratios have been synthesized used carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite...