Coincidence of the properties of ligand binding pockets in native proteins with those in proteins generated by computer simulations without selection for function shows that pockets are a generic protein feature and the number of distinct pockets is small. Similar pockets occur in unrelated protein structures, an observation successfully employed in pocket-based virtual ligand screening. The sm...

A 30-year-old man presented with headache, vomiting, altered sensorium and seizures. There was no history of trauma or surgery. On examination, he was unconscious with signs of meningeal irritation and asymmetrical pupils. Computed tomography (CT) scan of brain revealed pneumocephalus. He died immediately after the CT scan. He was later found to be immunocompetent. Computed tomography scan (fig...

The inhibition of protein-protein interactions is a promising strategy in anti-cancer therapy. A prominent example is the interaction between MDM2 and the tumor suppressor protein p53 that can be inhibited by small molecules identified in binding essays [1]. The structure-based design of such inhibitors suffers from the lack of welldefined binding pockets [2]. We therefore developed a pocket de...

A current growth industry is the organisation of meetings between scientists and those who are often referred to as 'soci-ety'. Behind the complicated but often stimulating discussions these meetings engender lies a profound schism between those close to science and technology and those who feel disenfranchised by it. There are many possible causes for this, including cryptic language, arroganc...

Comprehensive analysis and comparison of protein ligand-binding pockets are important to predict the ligands which bind to parts of putative ligand binding pockets. Because of the recent increase of protein structure information, such analysis demands a fast and efficient method for comparing ligand binding pockets. Previously we proposed a fast alignment-free method based on a simple represent...

The predominance of anaerobic bacteria in subgingival plaque samples suggests that the pocket environment is anaerobic. In the present investigation, a small oxygen tension (pO2) electrode was inserted into the base of the pocket and the pO2 was recorded. In addition, the plaque in these pockets was examined culturally and microscopically. The oxygen tension at the bottom of 36 pockets (5 to 10...

INTRODUCTION Metronidazole is the drug of choice in the treatment of periodontal pockets up to 5 mm in depth. It is topically applied--directly into the periodontal pockets. There are no registred trademark preparations for this purpose in the market of Serbia and Montenegro. The aim of our latest research was to test the efficacy of newly formulated preparation containing 25% metronidazole sus...

Air pockets, one kind of concrete surface defects, are often created on formed concrete surfaces during concrete construction. Their existence undermines the desired appearance and visual uniformity of architectural concrete. Therefore, measuring the impact of air pockets on the concrete surface in the form of air pockets is vital in assessing the quality of architectural concrete. Traditionall...