The gene encoding an integrase of Mason-Pfizer monkey virus (M-PMV) is located at the 3'-end of the pol open reading frame. The M-PMV integrase has not been previously isolated and characterized. We have now cloned, expressed, isolated, and characterized M-PMV integrase and compared its activities and primary structure with those of HIV-1 and other retroviral integrases. M-PMV integrase prefers...

The prevalence of degenerated cells in the thickened intima of cholesterol-fed animals suggested that necrotic regions might become a focus for lesion development by attracting histiocytes or monocytes. We propose that cholesterol-rich necrotic products scavenged by macrophages incite the accumulation of cholesteryl ester and the formation of cholesteryl ester droplets. The feasibility of this ...

In humans, the rostral part of the ventral premotor cortex (PMv), the homologue of F5 in monkeys, is known to be critically involved in shaping the hand to grasp objects. How does information about hand posture, that is processed in PMv, give rise to appropriate motor commands for transmission to spinal circuits controlling the hand? Whereas PMv is crucial for skilled visuomotor control of the ...

Action observation (AO), observing another individual perform an action, has been implicated in several higher cognitive processes including forming basic motor memories. Previous work has shown that physical practice (PP) results in cortical motor representational changes, referred to as use-dependent plasticity (UDP), and that AO combined with PP potentiates UDP in both healthy adults and str...

Switchgrass (Panicum virgatum) cultivars are currently under development as lignocellulosic feedstock. Here we present a survey of three established switchgrass experimental nurseries in Nebraska in which we identified Panicum mosaic virus (PMV) as the most prevalent virus. In 2012, 72% of 139 symptomatic plants tested positive for PMV. Of the PMV-positive samples, 19% were coinfected with its ...

The partial molar volume (PMV) is a thermodynamic quantity which contains important information about the solute-solvent interactions as well as the solute structure in solution. Additionally, the PMV is the most essential quantity in the analysis of the pressure effect on chemical reactions. This article reviews the recent developments in molecular theories of the PMV, especially the reference...

During surveillance of the swine population in Israel a haemagglutinating agent was isolated and identified as a paramyxovirus (PMV). Serological studies based on haemagglutination and neuraminidase inhibition (HI and NI) tests displayed a close antigenic relationship between the isolate and the prototype strain of a variety of the avian PMV serotype 3 (PMV-3). However, comprehensive HI and NI ...

The Mason-Pfizer monkey virus (M-PMV) was originally isolated from a spontaneous mammary adenocarcinoma of a female monkey. Searching for evidence of M-PMV in healthy rhesus monkeys has led to the recovery of similar isolates from cultures derived from normal mammary, fetal, and placental tissues. The viral morphology as well as the process of virus formation observed with the new isolates are ...

Evidence suggests that the role played by the adipocyte-derived hormone leptin in female reproductive physiology is mediated in part by neurons located within the ventral premammillary nucleus (PMV). Leptin activates PMV neurons; however, the intracellular signaling pathway and channel(s) involved remain undefined. Notably, leptin's excitatory and inhibitory effects within hypothalamic and brai...

BACKGROUND Acute liver failure (ALF) is a rapidly progressing and fatal disease for which liver transplantation (LT) is the only treatment. Posttransplant mechanical ventilation tends to be more prolonged in patients with ALF than in other LT patients. The present study examined the clinical effects of prolonged posttransplant mechanical ventilation (PMV), and identified risk factors for PMV fo...