OBJECTIVE To develop a composite score for measurement of disease activity in polymyalgia rheumatica (PMR) and assess its internal and external validity. METHODS A PMR activity score (AS) was designed and assessed for internal and external validity in two patient cohorts: 57 international patients evaluated primarily for development of the PMR-AS at baseline, weeks 4 and 24; and for validatio...

OBJECTIVES Evidence of the association of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) with the full range of cardiovascular diseases (CVDs) is limited. We examined their relationship with the first clinical presentation of the 12 most common CVDs in an unselected population-based cohort of men and women. METHODS We analysed CArdiovascular disease research using LInked Bespoke ...

Polymyalgia rheumatica (PMR) is considered to be a benign disease by some, while others think it is a more serious illness which required similar treatment to giant cell arteritis (GCA). The progress of 85 patients with PMR who presented to a district general hospital has been studied in an attempt to study this relationship. Thirty-eight patients had PMR alone, and 14 developed PMR and GCA wit...

From the Center for Cardiovascular Disease Prevention (ADP, NRC, PMR, JEB), the Donald W. Reynolds Center for Cardiovascular Research (ADP, NRC, PMR), the Leducq Center for Molecular and Genetic Epidemiology of Cardiovascular Disorders (PMR), the Division of Cardiovascular Medicine (PMR) and Preventive Medicine (ADP, NRC, JEM, PMR, JEB), Brigham and Women’s Hospital and Harvard Medical School, ...

OBJECTIVE To investigate the incidence of new cancer diagnoses in a community sample of patients with polymyalgia rheumatica (PMR). METHODS All incident cases of PMR in the UK General Practice Research Database (GPRD) (1987-99), without pre-existing cancer or vascular disease and treated with corticosteroids (n=2877) were matched with up to five age, sex and GP practice patients without PMR (...

Polymyalgia rheumatica (PMR) is a well-defined acute musculoskeletal inflammation of ageing people and characterized by clinical symptoms that may create some difficulties in the differential diagnosis with late (elderly) onset RA (LO-RA or EO-RA, respectively) as well as with LO-RA with PMR-like onset (LO-RA/PMR) [1]. PMR as an inflammatory condition of multifactorial aetiology is generally ch...

Background: Problems that arise during menstruation include pain before or during menstruation. Progressive Muscle Relaxation (PMR) techniques and Endorphin Massage (EM) therapy have been shown to be effective in controlling menstrual pain. The purpose of this study was to determine the difference in the effectiveness of pain intensity carried out by PMR therapy and EM therapy. Methods: Quasi...

BACKGROUND Obesity is a major public health problem in many poor countries where micronutrient deficiencies are prevalent. A partial meal replacement may be an effective strategy to decrease obesity and increase micronutrient intake in such populations. The objective was to evaluate the efficacy of a partial meal replacement with and without inulin on weight reduction, blood lipids and micronut...

Enterobacterial H-NS-like proteins and Pseudomonas MvaT-like proteins share low homology at the amino acid sequence level, but both can function as xenogeneic silencers and are included in the H-NS family of proteins. H-NS family members have dimerization/oligomerization and DNA-binding domains connected by a flexible linker and form large nucleoprotein complexes using both domains. Pmr, an Mva...

OBJECTIVES Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are common and frequently overlapping diseases. In this manuscript similarities and differences between these conditions have been assessed. METHODS A retrospective review of the literature was conducted. Reports emphasizing features in common and possible differences are reviewed. RESULTS GCA and PMR are characterized b...