As a result of observations madc by Roscnberg in the early 1960s~ a range of platinum compounds have been discovered which have significant anti-tumour properties (I, 2). The two prototype compounds originally mvcstigated are the cis isomers of diamminoplatinum(I1) dichloride and diammino-platinum(1V) tetrachloride. The stercochemistries are shown in Figure I . The t ~ m s i omers of these comp...

A series of new ethylenediamine (en) platinum(IV) complexes of the type Pt((IV))enX(2)A(2), with X(2) = cyclobutane-1,1-dicarboxylato (CBDCA), dichloro or bis(decanoato) and A = acetato, dodecanoato, tetradecanoato, hexadecanoato, octadecanoato, adamantanecarboxylato (Ad) or 3alpha, 12alpha-diformoxy-5beta-cholato (DFCA) were synthesized and characterized by elemental analysis, infrared and NMR...

Platinum compounds represent one of the great success stories of metals in medicine. Following the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large number of cisplatin variants have been prepared and tested for their ability to kill cancer cells and inhibit tumor growth. These efforts continue today with increased realization that new strategies are needed t...

successful complete regression of these large tumors in 63 to 100% of the animals. c1L@@@†• Chart 1. Structural diagrams of the 2 platinum compounds found to be active against Sarcoma 180 and Leukemia L1210 in mice: the octahedral complex, cis-Pt(I\')(NH3)@CL@and the square planar com plex, cis-Pt(II)(NH3)2Cl2. MATERIALS AND METHODS Random-bred Swiss white mice, obtained from Spartan Research...

Cisplatin and its analogues are first-line chemotherapeutic agents for the treatment of numerous human cancers. A major inconvenience in their clinical use is their strong tendency to link to sulfur compounds, especially in kidney, ultimately leading to severe nephrotoxicity. To overcome this drawback we prepared a variety of platinum complexes with sulfur ligands and analyzed their biological ...

Although ovarian carcinomas with mutated BRCA1 or BRCA2 are sensitive to platinum compounds, such carcinomas eventually develop platinum resistance. Previously, we showed that acquired resistance to cisplatin in BRCA2-mutated tumors can be mediated by secondary intragenic mutations in BRCA2 that restore the wild-type BRCA2 reading frame. Here, we show that secondary mutations of BRCA1 also occu...

The syntheses of nickel(II)porphyrins bearing palladium(II) or platinum(II) complexes at their periphery were performed. These new compounds characterized by standard spectroscopic techniques and studied electrochemistry. electrochemical data then compared with previously published porphyrin dimers linked metal ions like platinum(II). An X-ray structure one these species was obtained confirmed ...

In this paper, a micro-fluidic optimized process for the continuous flow synthesis of azo compounds is presented. The continuous flow synthesis of Sudan II azo dye was used as a model reaction for the study. At found optimal azo coupling reaction temperature and pH an investigation of the optimum flow rates of the reactants for the diazotization and azo coupling reactions in Little Things Facto...