Fourteen plant species collected in Iran and selected mainly on the basis of their antimicrobial and/or antifungal activities were evaluated for in vitro antiplasmodial and cytotoxic effects in a study designed to screen plant extracts with selective activity against Plasmodium falciparum. The methanol extracts of nine of the species tested exhibit activity against Plasmodium falciparum (MIC va...

background: malaria is well known for its fatalities worldwide, plasmodium vivax and the plasmodium falciparum are the two important species of malaria reported from pakistan and creating lots of morbidities across the country. method: study was conducted to determine the surveillance of malaria in south punjab by microscopy and polymerase chain reaction (pcr). result : 40 samples out of 100 pa...

background : malaria remains a serious public health problem with significant morbidity and mortal-ity. this study was conducted to identify whether ficolin-a could play an active role of against mala-ria infection. methods : the function of ficolin-a was analyzed in mouse model. the open reading frame of fico-lin-a was cloned from the liver of new born c57bl/6 mice by rt-pcr and then inserted ...

malaria is a major problem in tropical and sub-tropical countries, with high morbidity and mortality. splenectomy makes patients more susceptible to serious bacterial and parasitic infections. we report for the first time in iran a fatal case of plasmodium vivax malaria, confirmed by microscopic and molecu­lar (semi-nested multiplex pcr) tests in a patient who had undergone splenectomy due to h...

background: plasmodium vivax is the predominant species causes of malaria with about 90% total annual reported malaria in iran. this study conducted to determine the susceptibility of plasmodium vivax isolates to chloroquine in sistan and balochistan province, southeastern iran. methods: a total 270 subjects with symptomatic malaria and confirmed p. vivax infection completed the designed 28-day...

background: aurones are naturally occurring compounds that belong to flavenoids family and have antiplasmodial effects. this study investigated some new aurones derivatives against chloroquine sensitive plasmodium falciparum. here we report the synthesis , in vitro antiplasmodial activity and cytotoxic evaluation of 11 compound from derivatives of (z)-2- benzylidene-4, 6-dimethoxybenzofuran-3(2...

Quinine is the best studied drug for treating severe malaria in very young children. Quinine may be administered in pregnancy and, at therapeutic doses, malformations have not been reported. Some strains of quinine from Southeast Asia and South America have become resistant. Quinine is the treatment of choice for the drug-resistant severe Plasmodium falciparum. The antimalarial mechanism of qui...

anopheles stephensi is one of the main vectors of malaria in the world including south of iran. three geographical populations for an. stephensi have been defined, based on egg morphology. the aim of the current study is determining the ability of different geographical populations of an. stephensi in the transmission of plasmodium berghei using anka strain of this parasite. four geographical p...