Normal plasma contains inactive renin, which becomes active when plasma is dialyzed to pH 3.3 and to pH 7.5, or treated with pepsin or trypsin. Under optimal conditions, each of these procedures activated the same quantity of renin, which was not further increased by repeating or combining two procedures, thus suggesting that the same pool of inactive renin was activated by each procedure. When...

Normal plasma contains inactive renin, which becomes active when plasma is dialyzed to pH 3.3 and to pH 7.5, or treated with pepsin or trypsin. Under optimal conditions, each of these procedures activated the same quantity of renin, which was not further increased by repeating or combining two procedures, thus suggesting that the same pool of inactive renin was activated by each procedure. When...

In order to investigate the mechanisms of increased plasma inactive renin in diabetics with microvascular complications, changes in active and inactive renin with the progress of diabetes mellitus were studied, and effects of standing on inactive renin release and the relationship between plasma inactive renin and serum trypsin or protease inhibitors wee also studied. Inactive renin increased w...

Plasma renin activity, plasma renin concentration, and angiotensin II levels were measured in 63 normal children aged between 2 months and 12 years. The results showed that the high levels of renin and angiotensin II present in infancy remained above adult levels throughout the first decade of life but that there was a decline with age. Boys less than 8 years old had lower plasma renin activity...

Plasma renin activity (PRA) increases after acidification of plasma or exposure of plasma to cold temperatures. The purpose of the present study is to evaluate the hypothesis that these increases of PRA reflect inactivation of circulating renin inhibiting factors. In each of eight normotensive subjects, mean PRA increased (p < 0.01) after acidification of plasma by acid dialysis (98%), after ac...

FUKUCHI, S., TAKENOUCHI, T. and NAIKAJTSA, K. Effect of Furosemide Administration and Upright Position on Plasma Renin Activity and Angootensin ‡U in Hypertension. Tohoku J. exp. Med., 1973, 111 (1), 71-78 Both plasma renin activity and angiotensin ‡U during recumbency measured by radioimmuno assay, were normal in essential hypertension, chronic glomerulonephritis and bilateral renal artery ste...

The expression of the renin gene in rat kidneys was studied using mouse submaxillary gland renin complementary DNA. The length of rat renin messenger RNA (mRNA) was approximately 1600 nucleotides, similar to that of mouse submaxillary gland and kidney renin mRNA. Rat renin mRNA was quantified by a radiodensitometric complementary DNA hybridization assay. The effects of intense long-term stimula...

MEYER, PHILIPPE, JOEL MENARD, NIC~LAS PAPANICOLAOU, JEAN-M. ALEXANDRE$LAUDINE DEVAUX,AND PAUL MILLIEZ. Mechanism of renin release following furosemide diuresis in rabbit. Am. J. Physiol. 215(4) : 908-915. 1968.-Injection of furosemide (10 mg/kg, iv) into rabbits increased plasma renin activity within 7 min; plasma renin activity increased further throughout the course of the experiment and rvas...

In 106 patients with essential hypertension and different plasma renin activity several hormonal and metabolic factors were studied: urinary excretion of catecholamines, blood levels of cholesterol and triglycerides, levels of glycaemia and insulinaemia after glucose load and plasma fibrinolytic activity. The plasma renin activity in 46.2 percent of patients was normal, whereas in 25.5 percent ...

The expression of the renin gene in rat kidneys was studied using mouse submaxillary gland renin complementary DNA. The length of rat renin messenger RNA (mRNA) was approximately 1600 nucleotides, similar to that of mouse submaxillary gland and kidney renin mRNA. Rat renin mRNA was quantified by a radiodensitometric complementary DNA hybridization assay. The effects of intense long-term stimula...