Background: Women with epilepsy face difficult choices whether to continue antiepileptic drug treatment during pregnancy, as uncontrolled seizures carry great risk mother and fetus but continuing may have adverse effects on baby’s development. This study aimed at evaluating entry into developing brain. Methods: Anaesthetised pregna...

while fasting has been practiced for centuries, its beneficial effects was unknown until recently. this review tries to analyze the current literature of how fasting and intermittent fasting (if) could affect clinical pathological parameters, learning, mood and brain plasticity. the effects of different ways of fasting on metabolism and stress were also explored. animal experiments have elucida...

Neurosteroids are steroids that are produced in the central nervous system (CNS). While progesterone and dehydroepiandostendione (the precursors of testosterone) are among the identified neurosteroids, it is not clear that testosterone could be considered as a neurosteroid. The testosterone synthesis has been demonstrated in the brain of castrated frog, but not in the rat brain. In the present ...

Neurosteroids are steroids that are produced in the central nervous system (CNS). While progesterone and dehydroepiandostendione (the precursors of testosterone) are among the identified neurosteroids, it is not clear that testosterone could be considered as a neurosteroid. The testosterone synthesis has been demonstrated in the brain of castrated frog, but not in the rat brain. In the present ...

the goal of this study was to investigate the common clinical chemistry and distribution of xanthine oxidase (xo) in selected tissues of a mouse model of menopause. twenty four nmri female mice were divided into three groups: normal control (nc), and ovariectomized (ovx) groups and an estrogen-treated ovariectomized (ovx+e) group which received subcutaneous injection of estradiol benzoate (2 mg...

Objective(s): Nowadays, the electromagnetic field-emitting devices are used routinely in our lives. Controversial reports exist concerning the effects of mobile radiofrequency (RF) on different parts of the body, especially stress hormones. The main goal of the present work was to study the long-term effects of mobile RF900 MHz exposure with special focus on the adrenal gland pathophysiology an...

Abstract The treatment of brain tumors using chemo- and radio-sensitizers may be limited by a lack effective drug delivery. Radiation some cytotoxic therapies induce DNA damage, damage response (DDR) pathways modulate resistance to chemo-radiation therapy. Inhibiting DDR targeting ATM leads sensitization enhances cytotoxicity. purpose this study is determine the key pre-clinical pharmacokinetic...

objective febrile seizure is the most common convulsive disorder in childhood. the role of iron in metabolism of neurotransmitters and carrying oxygen to the brain suggests the possibility of a relationship between iron deficiency anemia and febrile seizures. the aim of this study was to investigate the relationship between iron deficiency anemia and febrile seizures. materials & methods this c...

The objective of this study was to evaluate the utility of brain tissue slices to determine the effect of plasma and brain tissue nonspecific binding on the brain-to-plasma ratio (K(p)). Mouse or rat brain slices (400 microm) were prepared using a McIlwain tissue chopper (Surrey, UK) and incubated with 1 microg/ml of compound at 37 degrees C either in a physiological buffer to determine the buf...