We present a 34-year-old female patient with methotrexate unresponsive longstanding plaque psoriasis who developed pustular psoriasis ten weeks after initiation of ustekinumab therapy. Given the lack of other side effects and the rapid initial response of the underlying plaque psoriasis, we opted against discontinuing ustekinumab therapy. Topical corticosteroids were added for the management of...

Plaque psoriasis is a common inflammatory disease that causes raised, flaky plaques or patches on the skin. An abnormal immune system can be an important cause of psoriasis. Risankizumab and secukinumab are biologic drugs injected under patient’s skin to treat different parts system. Both approved in U. S. E. moderate‐to‐severe plaque

Psoriasis, which presents as red, scaly patches on the body, is a common, autoimmune skin disease that affects 2 to 3 percent of the world population. To leverage recent molecular findings into the personalized treatment of psoriasis, we need a strategy that integrates clinical stratification with molecular phenotyping. In this study, we sought to stratify psoriasis patients by histological mea...

Nail psoriasis affects nearly 80% of patients with plaque psoriasis and is even more prevalent in patients with psoriatic arthritis. Nail psoriasis is not simply a cosmetic problem but one that effects the structure and function of the nail, resulting in negative psychological effects. The first level in management of nail psoriasis is patient education. The hierarchy of nail psoriasis therapy ...

psoriasis and pemphigus vulgaris are two inflammatory and autoimmune diseases. their concomitant occurrence in one patient is very rare. we describe a 57-year-old patient with a history of severe plaque type psoriasis for 2 years. after a few months, he presented with disseminated bullae and mucosal erosions which were documented as pemphigus vulgaris. both of the diseases were successfully con...

Background. Chronic plaque psoriasis is frequently associated with obesity. The effect of a low-calorie diet on psoriasis has not been investigated. Objective. The objective was to investigate whether moderate weight loss increases the therapeutic response to topical treatment in obese patients with chronic stable plaque-type psoriasis. Material and Method. A 24-week clinical trial was conducte...

Psoriasis is a common inflammatory skin disease with a wide range of presentation and a relapsing course. In its typical presentation, it is a scaly erythematous plaque with thick silvery white scale. Verrucous psoriasis is a rare form of psoriasis with a clinical characteristic and histological presentation, it presents as a warty erythematous plaque, with a narrow differential diagnosis with ...

Psoriasis is a chronic inflammatory, immune-mediated skin disorder that affects 1.5-1.8 million people in Italy. The most common form of the disease is chronic plaque psoriasis, affecting about 90% of psoriasis patients, with about 20%-30% of them suffering from a moderate or severe condition. Little information is available about the economic impact of psoriasis in European countries. The prim...

Background: Many efforts are made to find new and more effective treatments for psoriasis. Intralesional 5-Fluorouracil (5-FU) +epinephrine is a cheap option which can be administered with long intervals. The effectiveness of Pulse Dye Laser (PDL) on psoriasis has been already assessed. We decided to evaluate the effectiveness of 5-FU+epinephrine and compare it to betamethasone and PDL.</...

BACKGROUND Plaque-type psoriasis produces significant morbidity, has negative effects on patients' health-related quality of life (HRQoL), and represents an economic burden. OBJECTIVES The assessment of disease severity, HRQoL and health care in plaque-type psoriasis in everyday German medical practice. METHODS Details of patients with plaque-type psoriasis were recorded by 48 dermatologist...