background: a precise understanding of the mechanism of human neointimal stenoses and atherosclerotic fibrous plaques , which give rise to thromboses in vital arteries, requires a suitable animal model that would mimic the same characteristics well. we developed a rabbit model of neointimal stenosis and fibrotic plaque rupture in the carotid artery to visualize the lesion progress and to charac...

Histamine, beta-adrenergic amines, and prostaglandins inhibited hemolytic plaque formation by splenic leukocytes from immunized mice. The same agents had previously been shown to prevent both the IgE-mediated release of histamine from human basophils and the immunologically specific cytolytic activity of murine lymphocytes, through stimulation of the production of cyclic AMP in leukocytes. We t...

The cytopathic changes produced by bluetongue virus were first observed by Haig, McKercher & Alexander (1956) in monolayer roller tube cultures of primary lamb kidney ce ll s. Subsequently, Fernandes (1959) described the growth and cytopathic effects of a virulent as well as a homologous egg-adapted strain at the thirtysixth passage level, in cultures of human amnion (Fernandes), Chang liver, c...

Background: Plaque is the main cause of caries and periodontal disease. Caries and periodontal disease can be prevented by inhibiting dental plaque formation. To inhibit the formation of plaque, teeth must be brushed with toothpaste. According to previous studies, propolis contains apigenin and tt-farnesol classified as flavonoid that can inhibit the formation of dental plaque by inhibiting glu...

Atherosclerosis is responsible for the death of thousands of Americans each year. The carotid constriction model of plaque development has recently been presented as a model for unstable plaque formation in mice. In this study we 1) validate ultrasound biomicroscopy (UBM) for the determination of carotid plaque size, percent stenosis, and plaque development in live animals, 2) determine the sen...