The evolution of regular chorionic gonadotropin (CG) and hyperglycosylated CG are linked with the evolution of hemochorial placentation in primates. Recent research with humans shows that regular CG promotes spiral artery angiogenesis and hyperglycosylated CG controls invasion by implanting trophoblast cells. It is inferred that the evolution of regular CG and hyperglycosylated CG in early simi...

Data with regard to the proportion of congenital malformations found at birth are presented from a survey of 657 pairs of twins of known zygosity and placentation delivered in Aberdeen and Northeast Scotland between 1968 and 1979. There was an excess of malformed individuals from monozygotic (MZ) pairs, but this did not reach statistical significance. The possible effect of monochorionic placen...

Preeclampsia (PE) is the leading causes of maternal death worldwide as well a significant cause fetal morbidity and mortality, including growth restriction (FGR). The concept that PE FGR shared common etiology widely accepted, i.e., maladaptive response to impaired placentation. Normal placentation result dynamic integration cell proliferation, differentiation, migration, in which trophoblast c...

Based on the number of tissues separating maternal from fetal blood, placentas are classified as epitheliochorial, endotheliochorial or hemochorial. We review the occurrence of these placental types in the various orders of eutherian mammals within the framework of the four superorders identified by the techniques of molecular phylogenetics. The superorder Afrotheria diversified in ancient Afri...

Introduction. Abnormal placentation is a challenge of diagnostic and treatment for all perinatal health professionals. The most important risk factors the development pathological placental invasion have been identified as birth by previous cesarean section, placenta praevia advanced maternal age. Antenatal diagnosis can reduce morbidity mortality; it usually determined grayscale ultrasound con...

OBJECTIVES To evaluate the performance of screening for all stillbirths and those due to impaired placentation and unexplained or other causes using a combination of maternal factors, fetal biometry and uterine artery pulsatility index (UtA-PI) at 19-24 weeks' gestation and to compare this performance with that of screening by UtA-PI alone. METHODS This was a prospective screening study of 70...

Pathological placentation (placenta previa and placenta accreta) is one of the main problems in modern obstetrics, which negatively affects maternal perinatal mortality rates. The use technologies for timely diagnosis this pregnancy complication correct route patient allow to reduce blood loss significantly, save not only life mother child, but also uterus some cases.The objective: evaluate dia...

Invasion of trophoblasts into maternal uterine tissue is essential for establishing mature feto-maternal circulation. The trophoblast invasion associated with placentation is similar to tumor invasion. In this study, we investigated the role of KAI1, an antimetastasis factor, at the maternal-fetal interface during placentation. Mouse embryos were obtained from gestational days 5.5 (E5.5) to E13...

Natural killer (NK) cells are recruited into the uterine stroma during establishment of the hemochorial placenta and are proposed regulators of uterine spiral artery remodeling. Failures in uterine spiral artery remodeling are linked to diseases of pregnancy. This prompted an investigation of the involvement of NK cells in placentation. NK cell depletion decreased the delivery of proangiogenic ...

Defective placentation and subsequent placental insufficiency lead to maternal and fetal adverse pregnancy outcome, but their pathologic mechanisms are unclear, and treatment remains elusive. The mildly hypertensive BPH/5 mouse recapitulates many features of human adverse pregnancy outcome, with pregnancies characterized by fetal loss, growth restriction, abnormal placental development, and def...