background: nowadays, drug and observation are advised to patients with lymphocytic hypophysitis and in some cases with nonfunctioning pituitary macoadenoma, instead of surgery. case presentation: in this article, we report a woman with nonfunctional pituitary macroadenoma and panhypopitutarism and negative criteria for lymphocytic hypophysitis associated with increased liver enzymes. after thr...

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background: intracranial lesions of the pituitary gland are common pituitary adenomas, accounting for 6-10% of all symptomatic intracranial tumors. in this retrospective study, the clinicopathologic features and survival rate of pituitary adenomas were evaluated. methods: the present retrospective study was conducted on 83 patients with pituitary adenomas, referring to radiation oncology depart...

cushing’s syndrome is a rare endocrine disease characterized by hypercortisolemia caused by excess acth secreted by the pituitary. distinguishing pituitary sources from the ectopic sources of acth is challenging because of the limited accuracy of noninvasive assays. the test that offers the highest sensitivity and specificity is bilateral inferior petrosal sinus sampling (bipss). in patients wi...

During a 5-year experience with 32 adrenal tumors with different basic problems in the Department of Endocrinology , Taleghani Hospital, 25 were found pituitary dependent Cushing's syndrome, "Cushing's disease." The treatment of patients with Cushing's disease depends on the presence or absence of pituitary tumor. Ifno pituitary tumor is demonstrated, irradiation can be given to the pituit...

Background: Nowadays, drug and observation are advised to patients with lymphocytic hypophysitis and in some cases with nonfunctioning pituitary macoadenoma, instead of surgery. Case presentation: In this article, we report a woman with nonfunctional pituitary macroadenoma and panhypopitutarism and negative criteria for lymphocytic hypophysitis associated with increased liver enzymes. After thr...

Pituitary developmental defects lead to partial or complete hormone deficiency and significant health problems. The majority of cases are sporadic unknown cause. We screened 28 patients with pituitary stalk interruption syndrome (PSIS) for mutations in the FAT/DCHS family protocadherins that have high functional redundancy. identified seven variants, four which putatively damaging, FAT2 DCHS2 s...

background: cushing's disease is the most prevalent cause of endogenous adrenocorticotrophic hormone hypersecretion. the aim of this study was to document the current clinical practice pattern in the management of cushing's disease by iranian endocrinologists to determine their opinions and compare them with the current clinical practice guidelines.    methods: an eight-item questionnaire deali...