Low productivity, rising R&D costs, dissipating proprietary products and dwindling pipelines are driving the pharmaceutical industry to unprecedented challenges and scrutiny. In this article I reflect on the current status of the pharmaceutical industry and reasons for continued low productivity. An emerging 'symbiotic model of innovation', that addresses underlying issues in drug failure and a...

Formation of natural gas hydrate is a serious problem in the gas and oil industry because it can plug pipelines and destroy the equipment. This study aimes to evaluate the concentration effect of glycol ethers on their synergism with a commercial kinetic hydrate inhibitor (Luvicap 55W) in sweet natural gas-water systems at a constant temperature of 4 oC and pressure of 95 bar. Hydrate formation...

Optimal control, prevention and investigation of accidents, and detection of discrepancies in estimated gas supply and distribution volumes are relevant problems of trunkline operation. Efficient dealing with these production tasks is based on the numerical recovery of spacetime distribution of nonisothermal transient flow parameters of transmitted gas mixtures based on fullscale measurements i...

This paper presents research results within real-time production optimization and reservoir management at the Center for Integrated Operations in the Petroleum Industry (IO center). This includes life-cycle and long term issues like well location and target production rates. Further, results on short term production optimization, for instance the allocation of target production between wells an...

Energy efficient computing is a major concern in all EDA industry, due mainly to cost, reliability and feasibility: temperature and power are the main performance limiters. Dynamic Variable Stages Pipelines allows to improve processors and datapaths throughput while reducing their energy consumptions. When the clock frequency is lowered, more computations can be performed in a combinatorial way...

Sir Humphry Davy witnessed the first chlorine hydrate crystallizing in 1811. Couple of century later his discovery, natural gas hydrates has begun to play an important role in energy business. From being a mere chemical curiosity, they have proven to be a nuisance for the natural gas industry. The problem of hydrate induced blockage in “wet gas” flow systems has been widely reported and became ...

Developing a pipeline risk assessment tool in the upstream oil and gas industry can be a difficult process. Regardless of the intent (integrity management, resource allocation, compliance etc.), challenges in the form of resource limitations and data constraints need to be overcome to develop a functional risk assessment tool. This paper describes Talisman Energy’s experience in developing an i...