BACKGROUND Segmental pigmentation disorder (SegPD) is a rare type of cutaneous dyspigmentation. This hereditary disorder, first described some 20 years ago, is characterized by hypo and hyperpigmented patches on the trunk, extremities and less likely on the face and neck. These lesions are considered as a type of checkerboard pattern. CASE PRESENTATION Herein, we present a 26-year-old male wh...

Pigmentation disorders span the genetic spectrum from single-gene autosomal recessive disorders such as oculocutaneous albinism (OCA), the autosomal dominant disorder piebaldism to X-linked ocular albinism and multifactorial vitiligo. OCA connotes a group of disorders that result in hypopigmented skin due to decreased melanin production in melanocytes and loss of visual acuity. There are four n...

A 75-year-old woman with a history of hydroxychloroquinetreated cutaneous lupus erythematosus presented with a bilateral sharply demarcated macular hyperpigmentation on both forearms (Fig. 1) and a partial melanonychia of the right thumb nail. This pigmentation disorder developed gradually over a 6-month period. No retinal pigmentation and no systemic disorder were revealed. Dermoscopy of the n...

Dyskeratosis Congenita (DKC) is a rare progressive bone marrow disorder associated with multi-systemic involvement. It is also characterized by triad of abnormal skin pigmentation, nail dystrophy and mucosal leukoplakia. Liver cirrhosis and portal hypertension are said to be uncommon among these patients. We hereby report a case of an adult male who presented with pancytopenia, abnormal skin pi...

Aims: Pigmentation disorders are one of the main skin problems due to mustard gas exposure in chemically-injured veterans. The aim of this study as part of the Sardasht cohort study was to investigate the association between IL-6 and IL-4 and pigment disorders in chemically-injured veterans exposed to mustard gas. Materials & Methods: In this study, 500 subjects including 372 people expose...

conclusions the patients with diffuse pjs may be asymptomatic and without gastrointestinal or extragastrointestinal malignancies. introduction peutz-jeghers syndrome (pjs) is a rare disorder characterized by mucocutaneous perioral pigmentation, gastrointestinal hamartomatous polyposis, and an increased risk of malignancy. families with pjs may show a variable spectrum of manifestations in spite...

In Drosophila, the pattern of adult pigmentation is initiated during late pupal stages by the production of catecholamines DOPA and dopamine, which are converted to melanin. The pattern and degree of melanin deposition is controlled by the expression of genes such as ebony and yellow as well as by the enzymes involved in catecholamine biosynthesis. In this study, we show that the conserved TSC/...

Vitiligo is a pigmentation disorder involving 1% of the population. One of the first line depigmenting agents is monobenzyl ether of hydroquinone (MBEH). Repigmentation following sun exposure; however, can occur after successful treatment with MBEH. This study describes a 54-year-old gentleman who presented with a 7-year history of hyperpigmented lesions on his face following depigmentati...