Objective: To investigate the protective effect of Hedyotis diffusa (HD) on collagen induced arthritis (CIA) rats. Methods: 40 male Wistar rats were randomly divided into four groups: normal group (blank control, n = 10), CIA model group, HD low dose group and HD high dose group. After CIA rats were prepared successfully, HD extract was administrated orally with the dose of 6 g/(kg. d) and 12 g...

glaucoma, a group of multifactor ocular diseases, is the second leading cause of blindness worldwide. primary open angle (poa) is the most common type of glaucoma, characterized by progressive optic nerve degeneration. numerous genes and proteins have been revealed to be associated with poag, but the pathologic mechanisms of the disease are still poorly understood. proteomics, the collective st...

autoimmune lymphoproliferative syndrome (alps) is a prototypic disorder of abnormal lymphocyte homeostasis. in the september 2005 issue of the iranian journal of allergy, asthma and immunology, a patient with clinical features consistent with alps was described. although the clinical presentation was in favor of alps, a precise diagnosis needed more laboratory evaluations.

backgroud: protein-protein interaction, plays a key role in signal transduction in signaling pathways. different approaches are used for prediction of these interactions including experimental and computational approaches. in conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins interact which ca...

background: sustainable and commercial production of taxol as an anti cancer drug is a critical point to its clinical application. nowadays, hazel because of rapid growth and wide range distribution is considered as an alternative source of taxol. objective: to increase taxol production the cdna encoding 3-hydroxy-3-methylglutaryl-coa reductase (hmgr) from iranian hazel (genebank accession numb...

objective(s): the purpose of this study was to conduct a meta-analysis on human micrornas (mirnas) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. materials andmethods: pubmed, embase, web of science, ovid medline were used to search for endometriosis mirna expression profiling studies of endometriosis. the mirn...

transcatheter ablation of atrioventricular accessory pathway is the therapy of choice in symptomatic patients. the ablation of posteroseptal accessory pathways thas some important points due to its anatomical location. catheter ablation of posteroseptal accessory pathways via left side approach is time consuming with low success rate and higher complications. we performed successful transcathet...

background: echinococcus multilocularis is a tiny tapeworm, responsible for 0.3~0.5 million alveolar echinococcosis in humans. methods: we searched relevant papers published between 1981 and 2013 based on the database sources such as pubmed and google scholar, and collected and integrated the data for analysis. results: the parasite is able to use host-originated molecules to modulate its devel...

background and objectives: silymarin is a unique flavonoid complex with documented hepatoprotective properties. silybum  marianum hairy root culture as a source for producing silymarin has been an important strategy for study the cell signaling pathway. in the present investigation trichoderma strains- silybum marianum hairy root cultures interactions have been studied. methods: the effects of ...