Indian sago starch extracted from Tapioca roots finds its application not only as a food but also numerous commercial applications. In the present review we are discussing concisely the extraction, physiochemical properties, chemical modifications and pharmaceutical applications of Indian sago starch. The sago starch is a cheap, easily available, biodegradable and a versatile polymer. Starch ha...

gundelia tournefortii l. is a well known plant in mountains of iran and is found all over the country. it traditionally has some medicinal applications. in this research, gundelia tournefortii l. seed was studied as a source of edible oil. oil was extracted with immersion method using diethyl ether as a solvent. acidity, saponification, ester, iodine, peroxide and refractive indices, average mo...

densely functionalized 3-(4-chlorophenyl)-5-(3-hydroxy-4-etoxyphenyl)-4,5-dihydro-1h-pyrazole-1-carboxamide was  synthesized in an expedient manner through specification and transamidation  respectively, of ester-functionalized pyrazoles. this synthetic protocol allowed for three diversifying steps in which appendages on the pyrazole scaffold were adjusted to optimize inhibition of protein kina...

It has been more than two decades since neuraxial opioids first underwent rigorous clinical study for use in humans. The intraspinal route of administration is now commonly used to administer anesthetics and analgesics. Addition of opioids to intraspinal administered local anesthetic provides an effective and prolonged analgesia. However, the physiochemical properties of opioids may influence t...

In this issue of Blood, Ciciliano et al demonstrate that thrombus formation in ferric chloride (FeCl3) thrombosis models relies on physiochemical, rather than biological, mechanisms.

A diverse group of natural biological compounds bind to microtubules and suppress microtubule dynamics. Here we review the mechanism of microtubule assembly and dynamics as well as structural features that are important for nucleotide binding, GTP hydrolysis and stabilization of longitudinal and lateral protofilament contacts. Specific emphasis is placed upon the polar structure of the microtub...

The onset of human degenerative diseases in humans, including type 2 diabetes, cardiovascular disease, neurological disorders, neurodevelopmental disease and neurodegenerative disease has been shown to be related to exposures to persistent organic pollutants, including polychlorinated biphenyls, chlorinated pesticides, polybrominated diphenyl ethers and others, as well as to polynuclear aromati...