Many pharmaceutical products find their way into receiving waters, giving rise to concerns regarding their environmental impact. A procedure was proposed that enables ranking of the hazard to aquatic species and human health due to such products. In the procedure, hazard assessment is based on five of the pharmaceutical product's individual physico-chemical properties. These properties are aggr...

long term monitoring programme on brine shrimp ( artemia sp.) is being carried out by the environment agency, abu dhabi, united arab emirates (ead) with the prime purpose of understanding the population dynamics, ecology and habitat requirements of artemia at al wathba lake, situated within al wathba wetland reserve, which is an artificial wetland near abu dhabi city. the present study, being a...

A novel method for the in situ generation of catalytically active small metal nanoparticles, by anion extrusion on a parent porous copper chloropyrophosphate framework, has been developed to generate gold, platinum and palladium nanoparticles for sustainable catalytic oxidations using molecular oxygen as the oxidant. Transmission electron microscopy coupled with detailed structural and physico-...

A new methodology that combines the generalized topological indices (GTI) and the down hill simplex optimisation procedure has been developed to search for optimised quantitative structure–property relationship models. The structural interpretation of the optimal molecular descriptors is attained analytically by means of the GTIs decomposition in terms of geodesics (shortest paths) in the molec...

A chemical property space defines the adaptability of a molecule to changing conditions and its interaction with other molecular systems determining a pharmacological response. Within a congeneric molecular series (compounds with the same derivatization algorithm and thus the same brute formula) the chemical properties vary in a monotonic manner, i.e., congeneric compounds share the same chemic...

*Corresponding author: [email protected], 8 Tel +33-4 6714 4918 9 Fax +33-4 6714 4792 10 11 2008, Annals of Forest Sciences, 65, 307 12 13 Abstract Six inclined poplar I-69 (Populus deltoids cv. I-69/55) trees were collected for studying the influence 14 of growth stress level on wood properties. Growth stress indicator (GSI) was measured at 8 positions around the 15 periphery of each trunk at...

Physico-chemical profiling is a fundamental tool at the early stage of drug discovery in screening drug-like candidates. Complex physico-chemical profiling, including molecular properties such as solubility, ionization, lipophilicity and permeability, has been found to be of predictive power in ADME (absorption, distribution, metabolism, elimination). In the present thesis work, the physico-che...