Galantamine hydrobromide was subjected to different stress conditions (acidic, alkaline, thermal, photolytic and oxidative). Degradation was found to occur under acidic, photolytic and oxidative conditions, while the drug was stable under alkaline and elevated temperature conditions. A stability-indicating reversed-phase liquid chromatographic method was developed for the determination of the d...

In this paper, the photocatalytic (UV-A/TiO2) degradation of two steroid hormones: norethisterone and danazol in aqueous medium has been studied using immobilized titanium dioxide as photocatalyst. The photolytic degradation (degradation without photocatalyst) of the two hormones was also investigated. UV-A irradiation was provided by black light lamp 18 W. The photocatalytic and photolytic deg...

A photochemical reaction has been developed for the partial de-polymerization of sodium alginate, a polysaccharide utilized in medicine, pharmacy, basic sciences and foods. An aqueous solution of sodium alginate was photochemically depolymerized to approximately 40% of its average molecular weight using ultraviolet light in the presence of titanium dioxide catalyst at pH 7 over a period of 3h. ...

High yield photolytic reduction of a series of thiaphosphoranes Z p SR to give Z p H with UV-light-induced tri-n-butyltin hydride through phosphoranyl radical Z p is described. This reaction is inhibited by a-methylstyrene and initiated by a radical initiator such as azobisisobutyronitrile

A method is described for the preservation of iodopsin, the labile photopigment of daylight vision, by freeze drying in vacuo. The lipids released by the action of light on rhodopsin and iodopsin are found to be similar and to possess a labile absorption spectrum in chloroform, with a rising peak at about 390 mmicro and a declining peak in the region of 470 mmicro. After the change is complete ...

Neurons undergoing targeted photolytic cell death degenerate by apoptosis. Clonal, multipotent neural precursor cells were transplanted into regions of adult mouse neocortex undergoing selective degeneration of layer II/III pyramidal neurons via targeted photolysis. These precursors integrated into the regions of selective neuronal death; 15 +/- 7% differentiated into neurons with many characte...

BACKGROUND Cell-penetrating peptides (CPPs) can transport macromolecular cargos into live cells. However, the cellular delivery efficiency of these reagents is often suboptimal because CPP-cargo conjugates typically remain trapped inside endosomes. Interestingly, irradiation of fluorescently labeled CPPs with light increases the release of the peptide and its cargos into the cytosol. However, t...