BACKGROUND The exact pathogenetic mechanisms of Coats' disease remain unknown. In this report, we show two cases of Coats' disease that achieved a favorable prognosis with the combined treatment of intravitreal bevacizumab (IVB) injection prior to photocoagulation, although both initially resisted photocoagulation therapy. CASE PRESENTATIONS Case 1 was a 15-year-old boy with initial visual ac...

Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes and is a leading cause of visual decline and irreversible blindness. So we designed this study to investigate retrospectively the effect of preoperative photocoagulation on corneal endothelial cells after vitrectomy in patients with PDR.The study included 52 eyes of 46 patients with PDR complicated with vitreous hemor...

Objective: This study aimed to observe the clinical effects of laser photocoagulation in treating retinopathy of prematurity (ROP), and to explore the influence of anesthesia on the disease prognosis. Methods: The study involved the retrospective analysis of 312 eyes treated with laser photocoagulation. The prognosis of ROP was observed, and its relationships with such factors as the gestationa...

AIM To examine the clinical efficacy of contact transscleral retinal photocoagulation with a diode laser. METHODS Transscleral retinal photocoagulation was performed on 36 eyes. The conditions treated included peripheral retinal breaks associated with retinal detachments (30 eyes) and giant retinal tears (six eyes). Of the 30 eyes with retinal detachments, 28 underwent transscleral photocoagu...

An abnormal increase in the permeability of the outer blood-retinal barrier was induced in the eyes of adult pigmented rabbits after retinal xenon arc photocoagulation. The alteration of the blood-retinal barrier, which was assessed by vitreous fluorophotometry after systemic administration of sodium fluorescein, followed a well-defined pattern. Higher values, which were recorded during the fir...

PURPOSE Macular edema is one of the most serious adverse effects after retinal scatter laser photocoagulation. It has been suggested that the inflammatory reaction after photocoagulation may be involved in the pathogenesis of macular edema. This study was designed to evaluate quantitatively the inhibitory effects of argatroban, a direct thrombin inhibitor, on leukocyte-endothelial cell interact...

PURPOSE To report on 2 cases of aggressive posterior retinopathy of prematurity (ROP) treated with intravitreal ranibizumab (Lucentis(®)) and laser photocoagulation. METHODS Two premature females, born at 25 and 26 weeks' gestation with a birth weight of 530 and 550 g, respectively, with aggressive posterior ROP received combined treatment with laser photocoagulation and intravitreal ranibizu...

BACKGROUND Macular grid laser photocoagulation remains the standard treatment for macular edema secondary to branch retinal vein occlusion (BRVO). One possible strategy for treating macular edema is to inhibit VEGF activity by competitive binding of VEGF with an anti-VEGF antibody, suggesting the therapy option with bevacizumab. However, multiple injections of anti-VEGF may lead to complication...

Background: The aim of the study was to compare functional and structural outcomes of treatment for retinopathy of prematurity with diode laser photocoagulation and cryotherapy. Materials and methods: We examined 111 children aged 4 years, treated for retinopathy of prematurity by transpupillary diode laser photocoagulation or cryotherapy. Both functional (visual acuity, orthoptic status) and s...

purpose: to compare the results of intravitreal bevacizumb (ivb) injection alone or in combination with intravitreal triamcinolone acetonide (ivt) versus macular laser photocoagulation (mpc) as primary treatment of diabetic macular edema (dme). methods: in this randomized clinical trial, 150 eyes of 129 patients with clinical dme and no previous treatment were enrolled. the eyes were randomly a...