BACKGROUND Using esophageal pHmetry, nasal CPAP (nCPAP) has been shown to decrease acid gastroesophageal reflux (GER) in adult humans. Although both GER (mainly non-acid) and nCPAP use are very frequent in newborns, the effect of nCPAP on GER in early life is unknown. Having recently shown that the newborn lamb is a unique model for studying neonatal GER, our main objective was to assess the ef...

Recently clinical studies have proved without doubts that in patients affect by neurological diseases, like stroke, parkinsonism syndromes and others neurodegenerative pathologies, there is a very elevated incidence of swallowing disorders even severe. The disease can show up in a full blown way, with clinical evident signs like suffocation or frequent and sudden cough, at the moment in which t...

Introduction: The relationship between Ηelicobacter pylori (hp) gastritis, the most common infection worldwide and Gastroesophageal Reflux Disease (GERD), a major health problem in Western Countries, remains controversial. AIM: To investigate the association between hp infection and GERD and the impact of hp eradication on esophageal acid exposure and esophageal motility in hp-positive patients...

INTRODUCTION Several aspects of gastroesophageal reflux disease (GERD) have been studied, but the frequency of comorbidities is not yet fully understood. OBJECTIVES To study the prevalence of GERD comorbidities in a tertiary care hospital. METHODS We prospectively studied 670 consecutive adult patients from the outpatient department of our facility. A diagnosis was established using clinica...

BACKGROUND There is today a significant greater number of laparoscopic antireflux procedures for the surgical treatment of gastroesophageal reflux disease and there are yet controversies about the necessity of division of the short gastric vessels and full mobilization of the gastric fundus to perform an adequate fundoplication. AIM To verify the results of the surgical treatment of non-compl...

BACKGROUND The gastro-esophageal reflux disease (GERD) is one of the most frequent disease of the upper gastro-entheric tract. Surgical treatment is reserved to selected patients, affected by severe forms of disease and/or without compliance to medical therapy.In 95%-60% of the patients submitted to surgical antireflux intervention, a notable improvement of the quality of life is observed.Funct...

Introduction: Eosinophilic esophagitis (EE) is an entity characterized by esophageal symptoms with the presence of dense eosinophilia, in the absence of reflux disease excluded by pHmetry or lack of response to treatment with proton pump inhibitor. Various guidelines try to establish diagnostic criteria. Clinical Case: Teenager, 14 years old. A history of low birth weight from 19 months (p5) an...

OBJECTIVES Oesophageal pH monitoring is a useful test for the diagnosis of gastro-oesophageal reflux disease (GORD) but has some limitations related to the nasopharyngeal electrode. Recently, a telemetric catheter free system (CFS) (Bravo; Medtronic) was developed. The aim of this study was to determine the concordance of data between the conventional pH measurement system (CPHMS) and the CFS B...

BACKGROUND AND AIMS Acid gastro-oesophageal reflux is one of the most important causes of chronic cough. The response to acid suppression in these patients is not as good as in patients with heartburn but improvement with antireflux surgery has been reported, suggesting the involvement of a non-acidic gastric component in the refluxate. Less acidic reflux may produce symptoms such as regurgitat...

INTRODUCTION Gastroesophageal reflux disease (GERD) is probably one of the most prevalent diseases in the world that also compromises the quality of life of the affected significantly. Its incidence in Brazil is 12%, corresponding to 20 million individuals. OBJECTIVE To update the GERD management and the new trends on diagnosis and treatment, reviewing the international and Brazilian experien...