One hundred thirty-five infertile patients were enrolled to investigate the efficacy of phloroglucinol-induced inhibition of the endometrial fundocervical wave and its effect on in vitro fertilization (IVF). We found that phloroglucinol significantly inhibited (P<0.05) peristaltic fundocervical wave, suggesting a feasible way of application of phloroglucinol to suppress endometrial waves during...

In this study, we investigated whether phloroglucinol (1,3,5-trihydroxybenzene) has therapeutic effects in cellular and animal model of Parkinson's disease (PD). PD is the second most common, chronic and progressive neurodegenerative disease, and is clinically characterized with motor dysfunctions such as bradykinesia, rigidity, postural instability, gait impairment, and resting tremor. In the ...

The polyphenol-enriched fraction of an ethanolic hops extract (Humulus lupulus) was separated to provide four acylphloroglucinol-glucopyranosides (1-4). 1-(2-Methylpropanoyl)phloroglucinol-glucopyranoside 1 has been isolated from hops before, whereas 1-(2-methylbutyryl)phloroglucinol-glucopyranoside 2, known as multifidol glucoside, and 1-(3-methylbutyryl)phloroglucinol-glucopyranoside 3 were f...

Inspired by the remarkable adhesive capabilities to wet surfaces of the secretes of the brown alga Fucus serratus, novel glues have been designed and characterized. Formulations composed of phloroglucinol, alginate, and calcium ions are capable of adhering to a variety of surfaces. Rheological data show that the presence of phloroglucinol lowers the amount of Ca(2+) ions required for sol-gel tr...

Inhibiting the bioactivities of circulating endothelial progenitor cells (EPCs) results in significant inhibition of neovessel formation during tumor angiogenesis. To investigate the potential effect of phloroglucinol as an EPC inhibitor, we performed several in vitro functional assays using CD34(+) cells isolated from human umbilical cord blood (HUCB). Although a high treatment dose of phlorog...

BACKGROUND There is increasing evidence that phloroglucinol, a compound from Ecklonia cava, induces the apoptosis of cancer cells, eventually suppressing tumor angiogenesis. METHODOLOGY/PRINCIPAL FINDINGS This is the first report on phloroglucinol's ability to potentially inhibit the functional bioactivities of endothelial progenitor cells (EPCs) and thereby attenuate tumor growth and angioge...

Diabetes mellitus is often associated with long term vascular complications including neuropathy and nephropathy. Long lasting diabetic complications are known to cause abnormalities in the synthesis and transport of protein with the increase the net protein loss in the body. The aim of the present study was to evaluate the protective effect of phloroglucinol (150,200,250 mg/kg; per oral) on th...

A diacyl phloroglucinol derivative, (cyloclohexyl methylene) bisdiacyl phloroglucinol was previously shown to exhibit potent activity against replication of human immunodeficiency virus type 1 (HIV-1) in CD4+ CEM-GFP cells. In this report, we further investigated mechanism of antiviral activity of (cyloclohexyl methylene) bisdiacyl phloroglucinol. The compound inhibited HIV-1 replication in rep...

Phytochemical investigation of aerial parts of Helichrysum niveum (H. niveum) using different chromatographic methods including semi-preparative HPLC afforded three new (1-3) and six known (4-10) acylphloroglucinols alongside a known dialcohol triterpene (11). The structures of the isolated compounds were characterized accordingly as 1-benzoyl-3 (3-methylbut-2-enylacetate)-phloroglucinol (helin...

Metastasis is a challenging clinical problem and the primary cause of death in breast cancer patients. However, there is no therapeutic agent against metastasis of breast cancer cells. Here we report that phloroglucinol, a natural phlorotannin component of brown algae suppresses metastatic ability of breast cancer cells. Treatment with phloroglucinol effectively inhibited mesenchymal phenotypes...