BACKGROUND We assessed the role of extracellular signal-regulated kinases (ERKs) in Ang II-stimulated contraction and associated signaling pathways in vascular smooth muscle cells (VSMCs) from human small arteries. METHODS AND RESULTS VSMCs derived from resistance arteries (<300 microm in diameter) from subcutaneous gluteal biopsies of healthy subjects (n=8) were used to assess Ang II-stimula...

In the present paper, we introduced concept of generalized multi-valued contraction mappings, via class functions \(\Phi\) and \(\Psi\) Also proved some fixed point results for (\(\phi\),\(\mathfrak{F}\))- mappings on cone b-metric spaces over Banach algebra \(\mathfrak{V}\). The conditions existence uniqueness are investigated. We give an example to support our main result.

Abstract In this manuscript we introduce the notion of $(\alpha,\beta,\psi,\phi)$ ( ? , ? ? ? ) -interpolative contraction that unifies and generalizes significant concepts: Proinov type contractions, interpo...

Confocal microscopy and the H+-sensitive fluorophore carboxyseminaphthorhodafluor-1 (SNARF-1) were used to measure either intracellular pH (pHi) or extracellular pH (pHo) in isolated, arterially perfused rabbit papillary muscles. Single-excitation, dual-emission fluorescent images of the endocardial surface and underlying myocardium to a depth of 300 μm were simultaneously recorded from perfuse...

To investigate intracellular pH (pHi) in human resistance arteries in essential hypertension, vessels were obtained from small biopsies of skin and subcutaneous fat from 14 untreated patients, and the results were compared with those from 14 matched normotensive control volunteers. Segments of isolated resistance arteries were mounted in a myograph and loaded with the pH-sensitive fluorescent d...

In the present paper, we introduce notion of (\phi, \shi)-convex contraction mapping order m and establish a fixed point theorem for such mappings in complete metric spaces. The result extends generalizes well known Dutta Choudhary (Fixed Point Theory Appl. 2008 (2008), Art. ID 406368), Rhoades (Nonlinear Anal., 47(2001), 2683-2693), Istratescu (Ann. Mat. Pura Appl., 130(1982), 89-104) besides ...

In Xenopus embryos, the successive and rapid cell divisions that follow fertilization are accompanied by periodic oscillations of intracellular pH (pHi). Cycling of pHi occurs in phase with several other oscillatory activities, namely nuclear divisions, M phase-promoting factor (MPF) activity, and surface contraction waves (SCWs). We report that treatments that abolish cycling of MPF activity a...

Intracellular pH (pHi) was measured with a pH-sensitive microelectrode in voltage-clamped sheep cardiac Purkinje fibers while tension was simultaneously measured. All solutions were nominally CO2/HCO3 free and were buffered with Tris. The addition of NH4Cl (5-20 mM) produced an initial intracellular alkalosis that was associated with an increase of twitch tension. At the same time, a component ...