BACKGROUND The potential benefits of earthworm (Pheretima aspergillum) for healing have received considerable attention recently. Osteoblast and osteoclast activities are very important in bone remodeling, which is crucial to repair bone injuries. This study investigated the effects of earthworm extract on bone cell activities. METHODS Osteoblast-like MG-63 cells and RAW 264.7 macrophage cell...

In order to develop a better bioactive molecules with good efficacy, we synthesized a new series of Thiazolo [3,2-a] pyrimidine derivatives with good yield and studied their anthelmintic properties, structureactivity relationships (SARs). A new series of Thiazolo[3,2-a]pyrimidines have been synthesized through duff formylation, ‘One pot’ Biginelli reaction, cyclization followed by knoevenagel c...

A series of N-[3-{(1H-benzo[d]imidazol-2-ylthio) methyl}-5-mercapto-4H-1, 2, 4-triazol-4yl]-2-substituted phenoxy acetamide 6(a-g) were synthesized by the mixture of the compound of potassium 2-(2-(1H-benzo[d]imidazol-2-ylthio) acetyl) hydrazinecarbodithioate (4) and aryloxy acid hydrazide (5) in presence of hydrochloric acid. The predicted structures of the synthesized compounds were confirmed...

Bu-yang-huan-wu-tang (BYHWT) is a popular Traditional Chinese Medicine formula consisting of seven herbal medicines (Astragalus membranaceus, Angelica sinensis, Paeonia lactiflora, Ligusticum chuanxiong, Carthamus tinctorius, Amygdalus persica and Pheretima aspergillum), that has been used in China for centuries to overcome stroke-induced disability. To ensure the consistency of quality, a reli...

The current study is aimed to investigate and evaluate the therapeutic potential of the dialysed protein extract of the Indian earthworm Pheretima posthuma for antioxidant and anti-inflammatory activities. The antioxidant activity was assessed by calculating Total Phenolic Content, Reducing power and Nitric Oxide Radical Inhibition capacity of the prepared autolysed earthworm extract. The anti-...

A series of nine 2-arylidene-4-(4methoxy/phenoxy-phenyl)but-3-en-4-olides (I-IX) were screened against Pheretima posthuma earthworm species to assess the anthelmintic activity of the synthetic derivatives. The in vitro effects of compounds were evaluated at a concentration of 2mg/mL and time taken by the derivatives to paralyze and subsequently kill the worms was recorded. Synthetic butenolide ...