N-benzoyl-N'-phenylthiourea (BFTU) compound is similar to amprenavir derivatives in the urea compound, chloroquine -NH group, and benzene ring, which a potent antiviral. This study evaluated effect of lipophilic, electronic, steric parameters BFTU on antiviral activity Covid-19. In silico docking using Autodock 4.2 confirm pkCSM webserver predict bioavailability toxicity. The SARS-CoV-2 recepto...

Phenylthiourea (PTU) is commonly used for inhibiting melanization of zebrafish embryos. In this study, the standard treatment with 0.2 mM PTU was demonstrated to specifically reduce eye size in larval fish starting at three days post-fertilization. This effect is likely the result of a reduction in retinal and lens size of PTU-treated eyes and is not related to melanization inhibition. This is ...

The synthesis of heterocyclic thioureas from heterocyclic amines with phenylor methylisothiocyanate or CS2 is described. Seven new X-ray crystal structures are reported: In N-(3-pyridyl)-N0-phenylthiourea (Pna21, a = 10.1453(3), b = 17.6183(5), c = 6.4787(2), V = 1158.02(6), Z = 4) hydrogen-bonding results in formation of a 3D network consisting of helices, which form channels parallel to the c...

Carbohydrate-integrated isoxazolines were synthesized from 2-nitroglycals and sulfur ylides, with the aid of 1-phenylthiourea catalyst. The reactions proceeded via [4+1] annulations and upon subsequent rearrangement, afforded the corresponding isoxazolines in high yields with excellent diastereoselectivities (up to 95% de).