The effects of exogenous and endogenous adenosine on exocytotic noradrenaline release were studied in rat hearts perfused in situ. Exocytotic release of endogenous noradrenaline (determined by high pressure liquid chromatography) was induced by electrical stimulation of the left cervicothoracic ganglion. Exogenous adenosine significantly reduced noradrenaline overflow from the heart. This suppr...

1. White adipocytes were found to be more responsive than brown adipocytes to inhibition of lipolysis by the A1 adenosine receptor agonist phenylisopropyladenosine. 2. Radioligand binding studies with plasma membranes isolated from the two adipocyte types indicated differences in the properties of the A1 receptors. Kd values (high and low affinity) for phenylisopropyladenosine were higher in me...

There are several reports that adenosine and carbamazepine have pharmacodynamic interaction. I n this study the antinociceptive interaction o f these two agents was evaluated in mice by the hot plate test. Agents were injected intraperitoneally. 0.2 and 0.4 mg/kg doses of R-phenylisopropyladenosine (R-PIA) substantially showed antinociceptive effects. Carbamazepine had antinociceptive acti...

The purpose of the present study was to characterize adenosine receptors in human atrial and ventricular myocardium. In isolated electrically driven preparations, adenosine produced "direct" negative inotropic effects in atrial myocardium (AT). In ventricular myocardium (VE), it only had negative inotropic properties when force of contraction had been stimulated with isoprenaline ("indirect" ef...

background: in this study, the effects of three structural analogues of adenosine upon proliferation of human tumor cells were investigated. previous research showed a cytotoxic effect of adenosine via a3 receptor and a1 receptor and sometimes this effect was receptor independent. the researches showed a differential cytotoxic effect of adenosine and its a3 agonists on cancerous cells, while ot...

In adipocyte membranes, cholera toxin may ADP-ribosylate the islet-activating protein (IAP) substrate, under certain conditions. Covalent modification is maximal in the absence of a guanosine triphosphate; in the presence of 5'-guanylylimidodiphosphate, incorporation of [32P]ADP-ribose is markedly reduced. ADP-ribosylation by cholera toxin has similar functional consequences as does IAP-mediate...

UNLABELLED Cisplatin is a commonly used antineoplastic agent that produces ototoxicity that is mediated in part by increasing levels of reactive oxygen species (ROS) via the NOX3 NADPH oxidase pathway in the cochlea. Recent studies implicate ROS generation in mediating inflammatory and apoptotic processes and hearing loss by activating signal transducer and activator of transcription (STAT1). I...

there are several reports that adenosine and carbamazepine have pharmacodynamic interaction. i n this study the antinociceptive interaction o f these two agents was evaluated in mice by the hot plate test. agents were injected intraperitoneally. 0.2 and 0.4 mg/kg doses of r-phenylisopropyladenosine (r-pia) substantially showed antinociceptive effects. carbamazepine had antinociceptive actions e...

It is known that vasodilator effects of adenosine are mediated by A2 receptors in various animal species. Nevertheless, in several blood vessels there is evidence for vasodilator responses to some adenosine analogues, which are resistant to the antagonists of the different adenosine receptor subtypes, suggesting that they are not mediated by any of the known adenosine receptors. There are contr...