A new series of N-(5-Mercapto-1,3,4-thiadiazol-2-yl)-2-phenylacetamide derivatives (3a-3j) were synthesized via an amidation reaction using EDC and HOBt in acetonitrile solvent at room temperature condition. Chemical structures were characterized by 1H NMR, IR and MS spectroscopic methods and related melting points were also determined. The anticancer activity was evaluated using MTT procedure ...

TEI-1194, sodium 6-[D-(-)-alpha-(coumarin-3-carboxamide)-phenylacetamide] penicillanate and TEI-2012, sodium 6[D-(-)alpha-(8-hydroxy-coumarin-3-carboxamide)-phenylacetamide] penicillanate are new semisynthetic penicillin derivatives both possessing a broad spectrum of in vitro antibacterial activities. Minimal inhibitory concentrations of both agents were compared with carbenicillin. TEI-1194 a...

A series of 10 various 2-[5-(1-formyl-naphthalen-2-yloxymethyl)-[1,2,3]triazole-1-yl]-substituted phenyl acetamides (5a-5j) were synthesized through copper(I)-catalyzed 1,3-dipolar cycloaddition reaction 2-(prop-2-ynyloxy)naphthalene-1-carbaldehyde (2) and different 2-azido-N-phenylacetamide derivatives (4) under the assorted click chemistry pathway. Its specific biocompatibility to solidify mo...

that growth on phenylacetamide could not be attributed to any residual activity of the aliphatic amidase. It seemed clear that the wild type P. putida A87 is capable of producing two separate amidases and carries genes for the structure and regulation of both an aliphatic amidase and an aromatic amidase. Similar conclusions were reached for P . cepacia strain 716. P.putida strain A90 was partic...

A novel series of 2-(3-fluoro-4-nitrophenoxy)-N-phenylacetamide compounds were designed, synthesized and in vitro assessed for their antitubercular activities by a microdilution method. All the novel derivatives exerted potent or moderate active against M. tuberculosis H₃₇Rv, with MIC values ranging from 4 to 64 μg/mL. The most potent derivative 3m showed an identical MIC value of 4 μg/mL for b...