Dysfunction of β -glucocerebrosidase (GCase) has no hydrolytic activity in patients of Gaucher's disease and increasing the risk factor for Parkinson's disease occurrence. Pharmacological chaperone design has been used to treat with misfolded protein in related disease, which utilized a small compound to cause protein folding correctly. This study employed the world largest traditional Chinese ...

INTRODUCTION Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher disease (GD), which give rise to significant protein misfolding effects and result in progressive accumulation of glucosyl ceramide. The main treatment for GD is enzyme replacement therapy (ERT). The iminosugar glycosidase inhibitor N-(n-butyl)-1-deoxynojirimycin (miglustat, ...

the most common type of childhood-onset epilepsy syndrome is childhood absence epilepsy (cae) with well-defined electro clinical features but unknown pathological basis. the incidence of absence epilepsy is about 2 and 8 out of every 100 000 children up to the age of 16, and the prevalence is 2 and 10% of children with any form of epilepsy. children with cae suffer from high rate of pretreatmen...

Defining dose requirement, pharmacokinetics and pharmacodynamics Clinical anaesthetists administer doses of drugs to obtain various degrees of drug effect. Some anaesthetic drug effects, such as muscle relaxation, are relatively easy to quantitate, whereas others such as anaesthetic depth are much more difficult. Anaesthetic dose requirement can be defined as the dose of drug that produces a de...

Background: Breathlessness is a multifactorial problem caused by multiple pathways and thus lends itself to a range of interventions, each targeting a specific mechanism. For a start, the aging process affects respiratory function and decreases lung elasticity and respiratory muscle strength, which results in forced vital capacity reduction. Moreover, many conditions, such as chronic obstructiv...

objective(s): garlic (allium sativum l. family liliaceae) is well known in iran and its leaves, flowers, and cloves have been used in traditional medicine for a long time. research in recent decades has shown widespread pharmacological effects of a. sativum and its organosulfur compounds especially allicin. studies carried out on the chemical composition of the plant show that the most importan...

In view of the wide usage Triphala for large number therapeutic indications, ethno medicinal practice extract preparation viz. extracting three plants together (sample A) and mixing extracts prepared separately B), were compared. Both test samples analyzed with respect to their physicochemical, phytochemical pharmacological profiles. case physicochemical properties, ash values moisture content ...

conclusions the plants listed can be used as a prediction of rau management. of course, there are is no evidence for curing rau by some of these plants in allopathic medicine, and the further investigations in this area could lead to the discovery of a new drug evidence acquisition iranian medical sources were reviewed and effective plants used in the traditional treatment of rau were found and...