The aim of this study is to compare two different productions of Albanian and Canadian B-complex multivitamin tablets on the Albanian pharmaceutical market through various ‘in vitro’ pharmacopeias tests and argue about the regulatory legislative framework of drugstore sale of these products. Identification, weight uniformity, hardness and disintegration tests are carried out for the specific vi...

hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. today this technology has found its place in the array of pharmaceutical manufacturing operations. melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

In the pharmaceutical science, sintering has been described as the mechanism for the strengthening of the mechanical properties of consolidated pharmaceutical powders at elevated temperatures, for solid-bond formation during tablet compression, and for thermal curing of polymer-latex film coatings. The concept of sintering was applied in the investigation of the effect of heating on the mechani...

The growing interest of the pharmaceutical industry in Near Infrared-Chemical Imaging (NIR-CI) is a result of its high usefulness for quality control analyses of drugs throughout their production process (particularly of its non-destructive nature and expeditious data acquisition). In this work, the concentration and distribution of the major and minor components of pharmaceutical tablets are d...

Formulations that are able to control the release of drug have become an integral part of the pharmaceutical industry. In particular oral drug delivery has been the focus of pharmaceutical research for many years. This type of drug delivery has been at the centre of research due to its many benefits over conventional dosage. The focus of this review is on matrix tablets due to their widely use ...

calibration transfer method is evaluated by transferring multivariate models between two equivalent near-infrared (NIR) analyzers for the prediction of A an Active Pharmaceutical Ingredient (API) in tablets. The method includes selecting a few representative samples, building a transformation relation, and standardizing spectra. Backward and forward transfer approaches are compared. A practical...

Visual quality inspection plays an important rule in quality control. With visual inspection it is ensured that the inspected surface meets the requirements; that the surface is free of irregularities, such as cracks, dents, and scratches. Detection of irregularities can, however, be a challenging task, especially on complex surfaces, where it is necessary to differentiate between surface irreg...

Potassium permanganate is a mild antiseptic with astringent properties. It is used in dermatology to treat weeping skin conditions. Potassium permanganate tablets are commonly used in clinical practice. The 400 mg (1:1,000) tablets are diluted in four litres of water to give a dilution of 1:10,000 (0.01%) (British Medical Association and Royal Pharmaceutical Society of Great Britain, 2003).

In modern clinical practice, combination fixed - dose tablets have become a baseline foreffective therapy in many clinical conditions. The Hydrochlorothiazide (Hctz) (12.5mg) /Lisinopril (Lis) (10 mg) tablet is a combination drug for treatment of hypertension. In thisstudy, the tablets were prepared by wet granulation method and characterized in terms of weightvariation, hardness, friability, d...